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2012 Fiscal Year Final Research Report

Roles of the prostanoids in the pathogenesis of cardiovascular diseases

Research Project

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Project/Area Number 22390045
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionAsahikawa Medical College

Principal Investigator

USHIKUBI Fumitaka  旭川医科大学, 医学部, 教授 (50243035)

Co-Investigator(Kenkyū-buntansha) KOJIMA Fumiaki  旭川医科大学, 医学部, 助教 (30550545)
KASHIWAGI Hitoshi  旭川医科大学, 医学部, 助教 (60510609)
YUHKI Koh-ichi  旭川医科大学, 医学部, 准教授 (80302420)
Project Period (FY) 2010 – 2012
Keywordsプロスタノイド / プロスタグランジン / トロンボキサン / 循環器
Research Abstract

To clarify the roles of the prostanoids in the cardiovascular system, we employed several animal models showing similar pathophysiology with those seen in human diseases. Through the analysis of these animal models, we found novel actions of the prostanoids, which include the role of the EP4 and IP in the development of renal interstitial fibrosis, the role of the EP1 in the development of cisplatin-induced nephropathy and the potent inhibitory action of ONO1301 on platelet aggregation._4 Au

  • Research Products

    (9 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) Presentation (1 results)

  • [Journal Article] Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic hind limb model2013

    • Author(s)
      Aburakawa Y, Yuhki K, Ushikubi F, Hasebe N, et al
    • Journal Title

      Circ J

      Volume: 77 Pages: 1053-1062

  • [Journal Article] 17β-Estradiol is critical for the preovulatory induction of prostaglandin E_2 synthesis in mice2012

    • Author(s)
      Toda K, Yuhki K, Ushikubi F, Saibara T, et al
    • Journal Title

      J Gastroenterol. In press. Mol Cell Endocrinol

      Volume: 362 Pages: 176-182

  • [Journal Article] The intrinsic prostaglandin E_2-EP_4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice2012

    • Author(s)
      Nakagawa N, Yuhki K, Kojima F, Kashiwagi H, Ushikubi F, et al
    • Volume
      82
    • Pages
      158-171
  • [Journal Article] Potential roles of microsomal prostaglandin E synthase-1 in rheumatoid arthritis2011

    • Author(s)
      Kojima F, Ushikubi F, Crofford LJ, et al
    • Journal Title

      Inflamm Regen

      Volume: 31 Pages: 157-166

  • [Journal Article] Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake2011

    • Author(s)
      Mitsumori T, Ushikubi F, Narumiya S, et al
    • Journal Title

      Eur J Neurosci

      Volume: 34 Pages: 594-604

  • [Journal Article] Roles of prostanoids in the pathogenesis of cardiovascular system: Novel insights from knockout mouse studies2011

    • Author(s)
      Yuhki K, Kojima F, Kashiwagi H, Ushikubi F, et al
    • Journal Title

      Pharmacol Ther

      Volume: 129 Pages: 195-205

  • [Journal Article] Selective activation of the prostaglandin E_2 receptor subtype EP_2 or EP_4 leads to inhibition of platelet aggregation2010

    • Author(s)
      Kuriyama S, Kashiwagi H, Yuhki K, Kojima F, Ushikubi F, et al
    • Journal Title

      Thromb Haemost

      Volume: 104 Pages: 796-803

  • [Journal Article] M1 is a major subtype of muscarinic acetylcholine receptors on mouse colonic epithelial cells

    • Author(s)
      Khan MR , Ushikubi F, Taniguchi T, et al
    • Journal Title

      J Gastroenterol

      Volume: (in press)

  • [Presentation]

    • Organizer
      日本薬理学会総会・北部会

URL: 

Published: 2014-08-29  

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