2013 Fiscal Year Final Research Report
Molecular Imaging Research for Forefront of Cardiovascular Medicine
| Project/Area Number |
22390239
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kawasaki Medical School (2013)
National Institute of Radiological Sciences (2010-2012) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAGA Tsuneo 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, グループリーダー (40273445)
KOIZUMI Mitsuru 独立行政法人放射線医学総合研究所, イメージング研究センター, 上席研究員(平成23 年度より研究分担者から外れた) (20136352)
JIN Yong-nan 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 博士研究員(平成23 年度より研究分担者から外れた) (50568285)
YAMAHARA Ken-ichi 独立行政法人国立循環器病研究センター, 研究所・再生医療部, 室長 (50450888)
LI Xiao-kang 独立行政法人国立成育医療研究センター, RI 管理室, 室長 (60321890)
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| Co-Investigator(Renkei-kenkyūsha) |
OTANI Kentaro 独立行政法人国立循環器病研究センター, 研究所・再生医療部, 研究員 (50470191)
HATAYAMA Naoyuki 東京医科大学, 人体構造学講座, 助教 (80534792)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 核医学(PETを含む) / 分子イメージング |
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| Research Abstract |
(1) In molecular imaging research for angiogenic gene therapy, we demonstrated that HGF gene therapy alone could induce a dysfunctional microvasculature. (2) In molecular imaging research for regenerative medicine using bone marrow stem cells, we demonstrated that transplanted cells could be tracked and assessed quantitatively in vivo. (3) In molecular imaging research for cardiac transplantation following long-time preservation, we developed a new organ preservation method in a high-pressure CO/O2 gas mixture, and demonstrated that the function of transplanted hearts could be kept well by this new preservation method for 24 hours.
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Research Products
(9 results)
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[Presentation] Noninvasive spatial and temporal tracking of multilayered cell sheet on infarcted heart using reporter gene imaging2013
Author(s)
Otani K, Zeniya T, Kawashima H, Fukuda H, Hashikawa Y, Moriguchi T, Inubushi M, Iida H, Yamahara K
Organizer
American Heart Association Scientific Sessions 2013
Place of Presentation
Dallas Convention Center, Dallas, TX
Year and Date
20131116-20
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[Presentation] Tracking of transplanted stem cells in myocardial infarction model rat : validation of simultaneous dual-isotope SPECT imaging with Tc-99m and Tl-2012012
Author(s)
Zeniya T, Kawashima H, Otani K, Fukuda H, Hashikawa Y, Koshino K, Hori Y, Moriguchi T, Enmi J, Iguchi S, Yamamoto A, Miyake Y, Inubushi M, Iida H
Organizer
2012 World Molecular Imaging Congress
Place of Presentation
Dublin, Ireland
Year and Date
20120905-08
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[Presentation] Hepatocyte growth factor angiogenic gene therapy in rat myocardial infarct model : multimodal assessment with cine MRI, SPECT/CT, and two-photon excitation fluorescent microscopy2010
Author(s)
Jin YN, Inubushi M, Masamotoa K, Odaka K, Aoki I, Tsuji AB, Sagara M. Koizumi M, Saga T
Organizer
10th Congress of the World Federation of Nuclear Medicine and Biology
Place of Presentation
Cape Town, Republic of South Africa
Year and Date
20100918-23
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