2012 Fiscal Year Final Research Report
Stratification of gastroenterological tumors by genome-wide analysis of DNA methylation alteration.
| Project/Area Number |
22390255
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KANEDA Atsushi 東京大学, 先端科学技術研究センター, 特任准教授 (10313024)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUTSUMI Shuichi 東京大学, 先端科学技術研究センター, 特任准教授 (30345152)
UOZAKI Hiroshi 東京大学, 医学部附属病院, 講師 (10296246)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小腸大腸肛門外科学 |
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| Research Abstract |
DNA methylation analysis on genome-wide scale revealed three distint epigenotypes in gastric cancer and Epstein-Barr virus infection is the cause for extensive DNA methylation epigenotype. As for colorectal cancer, DNA methylation epigenotypes was found to be established already at adenoma stage; serrated adenoma showed high-methylation epigenotype with strong correlation to BRAF mutation, while non-serrated adenoma was classified into intermediate- and low-methylation epigenotypes.
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[Journal Article] Intermediate methylation epigenotype and its correlation to KRAS mutation in conventional colorectal adenoma2012
Author(s)
Yagi, K., Takahashi, H., Akagi, K., Matsusaka, K., Seto, Y., Aburatani, H., Nakajima, A., and Kaneda, A.†
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Journal Title
Am. J. Pathol.
Volume: 180
Pages: 616-625
DOI
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[Journal Article] Classification of Epstein-Barr virus positive gastric cancers by definition of DNA methylation epigenotypes2011
Author(s)
Matsusaka, K., Kaneda, A., Nagae, G., Ushiku, T., Kikuchi, Y., Hino, R., Uozaki, H., Seto, Y., Takada, K., Aburatani, H.,and Fukayama, M
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Journal Title
Cancer Res
Volume: 71
Pages: 7187-7197
DOI
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[Journal Article] Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma2010
Author(s)
Deng, Y.B., Nagae, G., Midorikawa, Y., Yagi, K., Tsutsumi, S., Yamamoto, S., Hasegawa, K., Kokudo, N., Aburatani, H., and Kaneda, A
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Journal Title
Cancer Sci
Volume: 101
Pages: 1501-1510
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