2012 Fiscal Year Final Research Report
Visualization of the sexual differentiation in the sexually dimorphic nucleus of the preoptic area.
| Project/Area Number |
22500297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKUMA Yasuo 東京医療学院大学, 保健医療学部, 教授 (70094307)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 性分化 / 視索前野性的二型核 / 可視化 / 細胞移動 / エストロゲン |
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| Research Abstract |
The sexually dimorphic nucleus in the preoptic area (SDN-POA) is larger in males than in females, however the mechanism of sexual differentiation of this structure remains largely unknown, except that androgen and/or estrogen during perinatal period cause the establishment of male-typical nuclei. We have shown recently that enhanced green fluorescent protein (EGFP) is expressed in the SDN-POA under the control of an estrogen receptor α gene promoter. The present study suggested that neural migration plays a key role in the sexual differentiation of the SDN-POA to visualize the nucleogenesis of the SDN-POA in vivo and in vitro.
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