2012 Fiscal Year Final Research Report
Analysis of mechanisms of heartbeat initiation in embryonic stage
| Project/Area Number |
22500365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takeshi 札幌医科大学, 医学部, 講師 (80363688)
MADEA Sachiko 札幌医科大学, 医学部, 助教 (80343391)
ICHISE Nobutoshi 札幌医科大学, 医学部, 助教 (60448610)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 心臓 / 自動能 / 発生分化 / カルシウムチャネル / 興奮収縮連関 |
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| Research Abstract |
In early embryonic stage, rat heart primordium begins the heatbeating. In cardiomyocytes from the early primordium, calcium current was observed. The calcium current was activated in pacemaker potential, and may be related to automaticity of heart. During this embryonic stage, gene expression and construction of protein molecule for the calcium channel (Cav1.3) were observed. The Cav 1.3 channels may be determinant for initiation of heart beat.
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