2012 Fiscal Year Final Research Report
The mechanism of loss of Erc gene ameliorates renal carcinogenesis and modulates integrin related pathway
| Project/Area Number |
22500389
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Toshiyuki 順天堂大学, 医学部, 准教授 (40260070)
HINO Okio 順天堂大学, 医学部, 教授 (90127910)
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| Project Period (FY) |
2010 – 2012
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| Keywords | Erc/mesothelin / Tsc2遺伝子 / GPIアンカー蛋白 / ノックアウトマウス / シグナル伝達 |
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| Research Abstract |
To investigate the position of Erc/mesothelin in signal pathway, we continue the studies and found that a novel function for Erc in the regulation of cell phenotype through controlling EGF receptor phosphorylation (Tyr1092), integrin β1 recycling and localization to lipid raft via a specific downstream effector pathway.
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