2012 Fiscal Year Final Research Report
Alteration of fucosylation and biomarker development in lung cancer
| Project/Area Number |
22501029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | Hokkaido University |
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Principal Investigator |
AKITA Hirotoshi 北海道大学, 大学院・医学研究科, 教授 (70222528)
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| Co-Investigator(Renkei-kenkyūsha) |
KINOSHITA Ichiro 北海道大学, 大学院・医学研究科, 准教授 (40343008)
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| Project Period (FY) |
2010 – 2012
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| Keywords | バイオマーカー / 肺癌 / 糖鎖 / 糖転移酵素〓1-6fucosyltransferase |
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| Research Abstract |
High 〓1-6 fucosyltransferase (〓1-6 FucT) expression is more frequently found in adenocarcinomas than squamous cell carcinomas, and is correlated with advanced pN status in adenocarcinomas. High 〓1,6-FT expression is associated with an unfavorable clinical outcome in potentially curatively resected and pStage I adenocarcinomas. These findings suggest that 〓1,6-FT and its core-fucosylated products could be promisingbiomarkers and therapeutic targets for NSCLCs, especially for adenocarcinomas.
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