2012 Fiscal Year Final Research Report
Development of the construction of multi contiguous chiral carbons by using recyclable chiral amine.
| Project/Area Number |
22590024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
OZEKI Minoru 京都薬科大学, 薬学部, 助教 (40465597)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Masayuki 京都薬科大学, 薬学部, 教授 (20239982)
HOSOI Shinzo 京都薬科大学, 薬学部, 准教授 (60209236)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 不斉合成 / キラルアミン / Michael 付加 / tandem 反応 / 多連続不斉炭素 |
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| Research Abstract |
We developed the novel tandem reaction to enable the construction of the multi contiguous chiral centers taking advantage of asymmetric Michael addition of chiral amine. As a result, 2 to 5 contiguous chiral centers were finely constructed in one pot utilizing five types of Michael addition, i.e., tandem Michael-alkylation, tandem Michael-oxidation, tandem Micheal-aldol, double Michael addition and double Michael-aldol reaction, which were triggered by a nucleophilic attack of chiral amine.
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[Journal Article] First asymmetric total synthesis of (+)-taiwaniaquinol D and (-)-taiwaniaquinone D by using intramolecular Heck reaction.2013
Author(s)
Minoru Ozeki, Megumi Satake, Toshinori Toizume, Shintaro Fukutome, Kenji Arimitsu, Shinzo Hosoi, TetsuyaKajimoto, Hiroki Iwasaki, Naoto Kojima, Manabu Node, Masayuki Yamashita
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Journal Title
Tetrahedron
Volume: 69
Pages: 3841-3846
DOI
Peer Reviewed
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[Journal Article] Synthesis of(±)-8-deisoprppyladunctin B. Chem.2012
Author(s)
Sayo Nomura, Kenji Arimitsu, Satoshi Yamaguchi, Yuya Kosuga, Yuko Kakimoto, Takanori Komai, Kazumasa Hasegawa, Akira Nlanishi Tamami Miyoshi, Hiroki Iwasaki, Minoru Ozeki, Ikuo Kawasaki, Ai Kurume, Shunsaku Ohta, Masayuki Yamashita
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Journal Title
Pharm. Bull.
Volume: 60
Pages: 94-103
DOI
Peer Reviewed
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[Journal Article] Alternative Synthesis of Radioiodinated Trisaccharide Derivatives,2-(4-125Iodophenyl)ethyl2-Acetamido-2-deoxy-SS-D-glucopyranosyl-(1→2)-α-D-mannopyranosyl-(1→6)-SS-D- glucopyranoside, and Preparation of Its Analogs Having Different Lengths of Alkyl Chains Instead of Ethyl Group: Acceptor Substrates ofN-Acetylglucosaminyltransferase V forin vivo Imaging.2011
Author(s)
Kenji Arimitsu, Tetsuya Kajimoto, Hiroyuki Kimura, Masahiro Ono, MinoruOzeki, Manabu Node, Yoshiro Ohmomo, Hideo Saji, Masayuki Yamashita
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Journal Title
Heterocycles
Volume: 83
Pages: 2779-2802
DOI
Peer Reviewed
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[Presentation] tandem型反応による多連続不斉炭素の構築.2012
Author(s)
泉谷すみれ,福留慎太郎,佐竹恵,樋爪稔典,中嶋大地,江川ほのか,岩崎宏樹,小島直人,小関稔,野出學,山下正行:キラルアミンの不斉Michael付加反応
Organizer
第62回日本薬学会近畿支部総会・大会
Place of Presentation
武庫川女子大学・薬学部
Year and Date
2012-10-20
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