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2012 Fiscal Year Final Research Report

Investigation on the production and/or metabolism of D-kynurenine in schizophrenia

Research Project

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Project/Area Number 22590147
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionToho University

Principal Investigator

FUKUSHIMA Takeshi  東邦大学, 薬学部, 教授 (00272485)

Co-Investigator(Kenkyū-buntansha) NISHIGUCHI Yoshikazu  東邦大学, 薬学部, 助教 (60459823)
Project Period (FY) 2010 – 2012
Keywords統合失調症 / D-キヌレニン / キヌレン酸 / D-アミノ酸酸化酵素 / D-トリプトファン / 蛍光検出
Research Abstract

D-Kynurenine (D-KYN) was metabolized to kynurenic acid (KYNA), which is an antagonist of NMDA receptor in brain, and D-amino acid oxidase (DAAO), one of the susceptible genes of schizophrenia, was found to be responsible for the production of KYNA from D-KYN. The metabolism of D-KYN to KYNA has been enhanced in the brain of animal model of schizophrenia, and the D-KYN was produced from D-tryptophan. In addition, a screening method for the inhibitor of DAAO was newly developed

  • Research Products

    (36 results)

All 2013 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (20 results) Remarks (1 results)

  • [Journal Article] Fluorimetric assay for D-amino acid oxidase activity in rat brain homogenate by using D-kynurenine as a substrate2012

    • Author(s)
      Kozaki A, Iwasa S, Hosoda S, Nishiguchi Y, Nakayama M, Ichiba H, Fukushima T
    • Journal Title

      Biosci Trends

      Volume: 6(5) Pages: 241-247

    • DOI

      DOI: 10.5582/bst.2012.v6.5.241

    • Peer Reviewed
  • [Journal Article] Alterations in extracellular tryptophan and dopamine concentrations in rat striatum following peripheral administration of D- and L-tryptophan: An in vivo microdialysis study2012

    • Author(s)
      Yoshihara S, Otani H, Tsunoda M, Ishii K, Iizuka H, Ichiba H, Fukushima T
    • Journal Title

      Neurosci lett

      Volume: 526 Pages: 74-78

    • DOI

      DOI: 10.1016/j.neulet.2012.07.046

    • Peer Reviewed
  • [Journal Article] A novel flow-injection analysis system for evaluation of antioxidants by using sodium dichloroisocyanurate as a source of hypochlorite anion2012

    • Author(s)
      Ichiba H, Hanami K, Yagasaki K, Tanaka M, Ito H, Fukushima T
    • Journal Title

      Drug Discoveries Ther

      Volume: 6(1) Pages: 44-48

    • DOI

      DOI: 10.5582/ddt.2012.v6.1.44

    • Peer Reviewed
  • [Journal Article] Determination of N-acetylaspartic acid concentration in the mouse brain using HPLC with fluorescence detection2012

    • Author(s)
      Song Z, Ge D, Ishii K, Yamada H, Toriumi K, Watanabe H, Nabeshima T, Fukushima T
    • Journal Title

      Biomed Chromatogr

      Volume: 26 Pages: 147-151

    • DOI

      DOI: 10.1002/bmc.1639

    • Peer Reviewed
  • [Journal Article] Alteration in the plasma concentration of a DAAO inhibitor, 3-methylpyrazole-5-carboxylic acid, in the ketamine-treated rats and the influence on the pharmacokinetics of plasma D-tryptophan2011

    • Author(s)
      Haruta N, Iizuka H, Ishii K, Yoshihara S, Ichiba H, Fukushima T
    • Journal Title

      Proc Jpn Acad Ser B.

      Volume: 87 Pages: 641-648

    • DOI

      DOI: 10.2183/pjab.87.641

    • Peer Reviewed
  • [Journal Article] Inhibition of D-amino acid oxidase activity by antipsychotic drugs evaluated by a fluorometric assay using D-kynurenine as substrate2011

    • Author(s)
      Iwasa S, Tabara H, Song Z, Nakabayashi M, Yokoyama Y, Fukushima T
    • Journal Title

      Yakugaku Zasshi

      Volume: 131 Pages: 1111-1116

    • URL

      https://www.jstage.jst.go.jp/article/yakushi/131/7/131_7_1111/_pdf

    • Peer Reviewed
  • [Journal Article] Fluorescence determination of D- and L-tryptophan concentrations in rat plasma following administration of tryptophan enantiomers using HPLC with pre-column derivatization2011

    • Author(s)
      Iizuka H, Ishii K, Hirasa Y, Kubo K, Fukushima T
    • Journal Title

      J Chromatogr B

      Volume: 879 Pages: 3208-3213

    • DOI

      DOI: 10.1016/j.jchromb.2011.02.014

    • Peer Reviewed
  • [Journal Article] Comparative study on kynurenic acid production in the rat striatum by tryptophan enantiomers: an in vivo microdialysis study2011

    • Author(s)
      Ishii K, Iizuka H, Ogaya T, Song Z, Fukushima T
    • Journal Title

      Chirality

      Volume: 23 Pages: E12-E15

    • DOI

      DOI: 10.1002/chir.20938

    • Peer Reviewed
  • [Journal Article] Enantiomeric separation of D, L-tryptophan and D, L-kynurenine by HPLC using pre-column fluorescence derivatization with R(-)-DBD-PyNCS2011

    • Author(s)
      Iizuka H, Hirasa Y, Kubo K, Ishii K, Toyo'oka T, Fukushima T
    • Journal Title

      Biomed Chromatogr

      Volume: 25 Pages: 743-747

    • DOI

      DOI: 10.1002/bmc.1525

    • Peer Reviewed
  • [Journal Article] Utilization of kynurenic acid produced from D-kynurenine in an in vitro assay of D-amino acid oxidase activity2010

    • Author(s)
      Song Z, Ogaya T, Ishii K, Ichiba H, Iizuka H, Fukushima T
    • Journal Title

      J Health Sci

      Volume: 56 Pages: 341-346

    • URL

      https://www.jstage.jst.go.jp/article/jhs/56/3/56_3_341/_pdf

    • Peer Reviewed
  • [Journal Article] Changes in the plasma concentrations of D-kynurenine and kynurenic acid in rats after intraperitoneal administration of tryptophan enantiomers2010

    • Author(s)
      Ishii K, Ogaya T, Song Z, Iizuka H, Fukushima T
    • Journal Title

      Chirality

      Volume: 22 Pages: 901-906

    • DOI

      DOI: 10.1002/chir.20850

    • Peer Reviewed
  • [Journal Article] Changes in extracellular kynurenic acid concentrations in rat prefrontal cortex after D-kynurenine infusion: An in vivo microdialysis study2010

    • Author(s)
      Ogaya T, Song Z, Ishii K, Fukushima T
    • Journal Title

      Neurochem Res

      Volume: 35 Pages: 559-563

    • DOI

      DOI: 10.1007/s11064-009-0099-1

    • Peer Reviewed
  • [Journal Article] Decreased L-tryptophan concentration in distinctive brain regions of mice treated repeatedly with phencyclidine

    • Author(s)
      Iizuka H, Watanabe S, Koshikawa M, Matsumoto Y, Aoyama Y, Ichiba H, Nabeshima T, Fukushima T
    • Journal Title

      Anal Bioanal Chem

    • DOI

      DOI: 10.1007/s00216-013-7010-2

    • Peer Reviewed
  • [Journal Article] Determination of L-tryptophan and L-kynurenine in human serum by using LC-MS after derivatization with (R)-DBD-PyNCS

    • Author(s)
      Ohashi H, Iizuka H, Yoshihara S, Otani H, Kume M, Sadamoto K, Ichiba H, Fukushima T
    • Journal Title

      Int J Trp Res

    • Peer Reviewed
  • [Journal Article] Enantiomeric separation of tolperisone and eperisone by reversed-phase HPLC with cellulose tris(3-chloro-4-methylphenylcarbamate)-coated chiral column

    • Author(s)
      Owada Y, Takahashi M, Iwasa S, Ichiba H, Sadamoto K, Fukushima T
    • Journal Title

      Biomed Chromatogr

    • DOI

      DOI: 10.1002/bmc.2892

    • Peer Reviewed
  • [Presentation] ケタミン連続投与ラット血漿中トリプトファン及びその代謝物濃度の変動解析2013

    • Author(s)
      粂 美里
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
  • [Presentation] Determination of tryptophan and kynurenic acid concentrations in rats after intraperitoneal administration of tryptophan enantiomers2012

    • Author(s)
      Takeshi Fukushima
    • Organizer
      13th International Society for Tryptophan Research (ISTRY 2012)
    • Place of Presentation
      Sydney (Australia)
    • Year and Date
      2012-11-09
  • [Presentation] Increased kynurenic acid concentration in rat plasma by repeated ketamine administration2012

    • Author(s)
      Misato Kume
    • Organizer
      13th International Society for Tryptophan Research (ISTRY 2012)
    • Place of Presentation
      Sydney (Australia)
    • Year and Date
      2012-11-09
  • [Presentation] Fluorimetric determination of L-tryptophan in serum or brain homogenate of Sprague-Dawley rats by HPLC using precolumn fluorescence derivatization with R(-)-DBD-PyNCS2012

    • Author(s)
      Hideaki Iizuka
    • Organizer
      13th International Society for Tryptophan Research (ISTRY 2012)
    • Place of Presentation
      Sydney (Australia)
    • Year and Date
      2012-11-08
  • [Presentation] ラット脳ホモジネート中D-アミノ酸酸化酵素活性の蛍光アッセイ法の開発2012

    • Author(s)
      神前杏奈
    • Organizer
      第56回 日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-13
  • [Presentation] ラット線条体マイクロダイアリシスによるD-およびL-トリプトファン 投与時における脳内トリプトファン およびドパミン濃度の変動解析2012

    • Author(s)
      大谷隼斗
    • Organizer
      第56回 日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-13
  • [Presentation] 市販中枢作用薬のD-アミノ酸酸化酵素活性阻害効果の検討2012

    • Author(s)
      田原翔志
    • Organizer
      第25回 バイオメディカル分析科学シンポジウム(BMAS 2012)
    • Place of Presentation
      東京
    • Year and Date
      2012-08-09
  • [Presentation] Determination of neuroactive compounds by HPLC with fluorescence detection in pre-clinical and clinical researches (Keynote Lecture IV)2011

    • Author(s)
      Takeshi Fukushima
    • Organizer
      The 7th Joint Seminar on Biomedical Sciences
    • Place of Presentation
      Hat Yai (Thailand)
    • Year and Date
      20111013-1014
  • [Presentation] (R)-(-)-DBD-PyNCSを用いるプレカラム蛍光誘導体化法によるマウス脳内トリプトファンのHPLC-蛍光定量2011

    • Author(s)
      渡邉祥子
    • Organizer
      第33回日本トリプトファン研究会学術集会
    • Place of Presentation
      船橋
    • Year and Date
      2011-12-04
  • [Presentation] Fluorescent assay for D-amino acid oxidase Inhibitor utilizing the production of kynurenic acid2011

    • Author(s)
      岩佐澄子
    • Organizer
      第55回 日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-10-08
  • [Presentation] R(-)-DBD-PyNCSを用いるプレカラム蛍光誘導体化によるトリプトファン光学異性体腹腔内投与におけるラット血漿中のD-およびL-トリプトファンのHPLCによる蛍光定量2011

    • Author(s)
      飯塚英昭
    • Organizer
      第55回 日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-10-08
  • [Presentation] キヌレン酸生成を活用するD-アミノ酸酸化酵素阻害物質の新規蛍光アッセイ法2011

    • Author(s)
      岩佐澄子
    • Organizer
      第7回 D-アミノ酸研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-09
  • [Presentation] ラット脳マイクロダイアリシスによる Trp 光学異性体腹腔内投与時のキヌレン酸変動解析2011

    • Author(s)
      石井香那
    • Organizer
      日本薬学会第131 年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
  • [Presentation] HPLCを用いる脳および血漿中トリプトファン代謝物の蛍光定量2011

    • Author(s)
      福島 健
    • Organizer
      第11回 関東支部談話会
    • Place of Presentation
      東京
    • Year and Date
      2011-03-18
  • [Presentation] D-アミノ酸酸化酵素によるD-キヌレニンからキヌレン酸への代謝生成とその応用2010

    • Author(s)
      福島 健
    • Organizer
      第32回 日本トリプトファン研究会
    • Place of Presentation
      彦根
    • Year and Date
      2010-12-05
  • [Presentation] Trp光学異性体投与によるラット血漿及び脳内キヌレン酸の変動解析2010

    • Author(s)
      石井香那
    • Organizer
      第32回 日本トリプトファン研究会
    • Place of Presentation
      彦根
    • Year and Date
      2010-12-05
  • [Presentation] HPLC-蛍光検出による生体分子の定量とその応用研究 ~D-serine やNAAの定量法の話を中心に2010

    • Author(s)
      福島 健
    • Organizer
      名城大学学術フロンティア推進事業特別講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-12-03
  • [Presentation] Comparative study on the kynurenic acid production in rat between tryptophan enantiomers2010

    • Author(s)
      Takeshi Fukushima
    • Organizer
      22nd International Symposium on Chirality (ISCD 2010)
    • Place of Presentation
      Sapporo
    • Year and Date
      2010-07-14
  • [Presentation] HPLCによる生体分子の蛍光定量法とその応用(教育講演)2010

    • Author(s)
      福島 健
    • Organizer
      第14回 神経科学領域における分子モニタリングシンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2010-06-04
  • [Presentation] ラット脳マイクロダイアリシスによるTrp光学異性体投与時のTrp及びその代謝物の変動解析2010

    • Author(s)
      石井香那
    • Organizer
      第14回 神経科学領域における分子モニタリングシンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2010-06-04
  • [Remarks]

    • URL

      http://www.lab.toho-u.ac.jp/phar/Analchem/index.html

URL: 

Published: 2014-08-29  

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