2012 Fiscal Year Final Research Report
Development of new diagnostic methods for bladder cancer using GFP expressing adenovirus vector
| Project/Area Number |
22591767
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
KAKU Haruki 岡山大学, 岡山大学病院, 講師 (60346426)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Masami 岡山大学, 岡山大学病院, 准教授 (70444677)
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| Co-Investigator(Renkei-kenkyūsha) |
HUJIWARA Toshiyuki 岡山大学, 医歯薬学総合研究科, 教授 (00304303)
KAGAWA Shunnsuke 岡山大学, 岡山大学病院, 講師 (00362971)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 緑色蛍光タンパク質 / ウイルスベクター / 膀胱癌 / プラスミド |
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| Research Abstract |
Usefulness of a diagnostic novel adenoviralvector Telomescan, which proliferates specifically in cancer cells and expresses green fluorescent protein (GFP), in the detection of various bladder cancer cells, was demonstrated. In addition, the usefulness of the luciferase and GFP expression plasmids (hTERT-AdTSTA-luciferase and GFP) as next-generation cancer-specific expression systems was also demonstrated in a various types of bladder cancer cells. Using these tools, we expect that detection of disseminating cancer cells becomes possible in a wide range of cancer diseases.
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Author(s)
Oishi K, Miyamoto Y, Saito H, Murase K, Ono K, Sawada M, Watanabe M, Noguchi Y, Fujiwara T, Hayashi S, Noguchi H
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Journal Title
PLoS One
Volume: 8
Pages: e57046
Peer Reviewed
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[Journal Article] Clinical significance of CD24 as a predictor of bladder cancer recurrence2013
Author(s)
Chunxiao Liu, Shaobo Zheng, Haiyan Shen, Kai Xu, Jie Chen, Hulin Li, Yawen Xu, Abai Xu, Binshen Chen, Haruki Kaku, Yasutomo Nasu, Hiromi Kumon, Peng Huang, Masami Watanabe
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[Journal Article] Implications of transcriptional factor2012
Author(s)
Huang P, Chen J, Wang L, Na Y,Kaku H, Ueki H, Sasaki K, Yamaguchi K, Zhang K, Saika T, Nasu Y, Watanabe M, Kumon H
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Journal Title
OCT-4, in human bladder malignancy and tumor recurrence
Volume: 29
Pages: 829-34
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[Journal Article] A novel gene expression system for detecting viable bladder cancer cells2012
Author(s)
Ueki H Watanabe M, Kaku H, , , , , , , , , , . Huang P Li SA Ochiai K Hirata T Noguchi H Yamada H Takei K Nasu Y Kashiwakura Y Kumon H
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Journal Title
International Journal of Oncology
Volume: 41
Pages: 135-40
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[Journal Article] In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy.2010
Author(s)
Kojima T, Watanabe Y, Hashimoto Y, Kuroda S, Yamasaki Y, Yano S, Ouchi M, Tazawa H, Uno F, Kagawa S, Kyo S, Mizuguchi H, Urata Y, Tanaka N, Fujiwara T.
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Journal Title
Ann Surg
Volume: 251
Pages: 1079-86
Peer Reviewed
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