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2012 Fiscal Year Final Research Report

Analysis of the regulation of androgen receptor by renin-angiotensin system in prostate cancer

Research Project

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Project/Area Number 22591774
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionYokohama City University

Principal Investigator

UEMURA Hiroji  横浜市立大学, 附属病院, 准教授 (50244439)

Co-Investigator(Kenkyū-buntansha) KUBOTA Yoshinobu  横浜市立大学, 医学研究科, 教授 (10106312)
Project Period (FY) 2010 – 2012
Keywords前立腺癌 / アンドロゲンレセプター / レニン-アンジオテンシン系
Research Abstract

We have confirmed that renin-angiotensin system have the potential to Regulate the expression of androgen receptor in prostate cancer cells via in vitro and in vivo experiment. Furthermore, we conducted a clinical study to confirm whether angiotensin II receptor blocker (ARB) would influence the development of prostate cancer .As a result, ARB has the potential to inhibit the expression of androgen receptor through AT1 receptor. Furthermore, clinical study revealed that ARB treatment delayed PSA risingin patients with PSA recurrence after prostatectomy.

  • Research Products

    (37 results)

All 2013 2012 2011 2010

All Journal Article (13 results) (of which Peer Reviewed: 12 results) Presentation (24 results)

  • [Journal Article] Thearpeutic targeting of angiotensin II receptor type 1 to regulate androgen receptor in prostate cancer2012

    • Author(s)
      S Takahashi, H Uemura, A Seeni, M Tang, M Komiya, N Long, H Ishiguro, Y Kubota and T Shirai
    • Journal Title

      Prostate

      Volume: 72(14) Pages: 1559-72

    • Peer Reviewed
  • [Journal Article] Identification of miR-30d as a novel prognostic maker of prostate cancer2012

    • Author(s)
      Kobayashi N, Uemura H, Nagahama K, Okudela K, Furuya M, Ino Y, Ito Y, Hirano H, Inayama Y, Aoki I, Nagashima Y, Kubota Y, Ishiguro H.
    • Journal Title

      Oncotarget

      Volume: 3(11) Pages: 1455-71

    • Peer Reviewed
  • [Journal Article] Usefulness of Perflubutane Microbubble-Enhanced Ultrasound in Imaging and Detection of Prostate Cancer: Phase 2 Multicenter Clinical Trial.2012

    • Author(s)
      H Uemura, F Sano, A Nomiya, T Yamamoto, M Nakamura, Y Miyoshi, K Miki, K Noguchi, S Egawa, Y Homma and Y Kubota
    • Journal Title

      World J Urol

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Uemura to case 2 discussion: Castration-resistant prostate cancer2012

    • Author(s)
      H Uemura, Answer by Dr
    • Journal Title

      Int J Urology

      Volume: 19 Pages: 379-381

  • [Journal Article] Possible Anti-tumor Activity of Initial Treatment withZoledronic Acid with Hormonal Therapy for Bone-Metastatic Prostate Cancer in Multicenter Clinical Trial2012

    • Author(s)
      H Uemura, M Yanagisawa, I Ikeda, K Fujinami, A Iwasaki, S Noguchi, KNoguchi, Y Kubota
    • Journal Title

      Int J Clin Oncol

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] The potential of FDG-PET/CT for detecting prostate cancer in patients with an elevated serum PSA level2011

    • Author(s)
      R Minamimoto, H Uemura, F Sano, H Terao, Y Nagashima, S Yamanaka, K Shizukuishi, U Tateishi, Y Kubota, T Inoue.
    • Journal Title

      Ann Nucl Med

      Volume: 25 Pages: 21-27

    • Peer Reviewed
  • [Journal Article] Engagement of renin-angiotensin system in prostate cancer2011

    • Author(s)
      H Uemura, K Hoshino, Y Kubota.
    • Journal Title

      Curr Cancer Drug Targets

      Volume: 11(4) Pages: 442-450

    • Peer Reviewed
  • [Journal Article] Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis2011

    • Author(s)
      K Endoh, M Nishi, H Ishiguro, H Uemura,Y Miyagi, I Aoki, H Hirano, Y Kubota, A Ryo.
    • Journal Title

      Prostate

      Volume: 72(6) Pages: 626-637

    • Peer Reviewed
  • [Journal Article] The co- -6 in prostate cancer tissue correlates with biochemical recurrence2011

    • Author(s)
      Ishiguro H, Akimoto K, Nagashima Y, Kagawa E, Sasaki T, Sano JY, Takagawa R, Fujinami K, Sasaki K, Aoki I, Ohno S, Kubota Y, Uemura H.
    • Journal Title

      Cancer Sci

      Volume: 102(8) Pages: 1576-1581

    • Peer Reviewed
  • [Journal Article] Regulation of androgen receptor expression through angiotensin II type 1 receptor in prostate cancer cells2011

    • Author(s)
      K Hoshino, H Ishiguro, J Teranishi, S Yoshida, S Umemura, YKubota, H Uemura
    • Journal Title

      Prostate

      Volume: 71 (9) Pages: 964-975

    • Peer Reviewed
  • [Journal Article] Contrast-enhanced ultrasonography of the prostate: Various imaging findings that indicate prostate cancer2011

    • Author(s)
      F Sano, H Terao, T Kawahara, Y Miyoshi, T Sasaki, K Noguchi, Y Kubota, H Uemura
    • Journal Title

      BJU Int

      Volume: 107(9) Pages: 1404-1410

    • Peer Reviewed
  • [Journal Article] High-grade invasive urothelial carcinoma with focal plasmacytoid differentiation successfully treated by transurethral resection followed by chemoradiotherapy2011

    • Author(s)
      Kawahara T, Oshiro H, Sekiguchi Z, Ito H, Makiyama K, Uemura H, Kubota Y
    • Journal Title

      Int J Urol

      Volume: 18(12) Pages: 851-3

    • Peer Reviewed
  • [Journal Article] Analysis of NSAID-activated gene-1 (NAG-1) expression in prostatecancer2010

    • Author(s)
      T Kawahara, H Ishiguro, KHoshino, J Teranishi, Y Miyoshi, Y Kubota , H Uemura
    • Journal Title

      Urol Int

      Volume: 84 Pages: 198-202

    • Peer Reviewed
  • [Presentation] Possibility and Limitation of Androgen Receptor as a Molecular Target for Prostate Cancer2013

    • Author(s)
      H Uemura
    • Organizer
      19th International Charles Heidelberger Symposium on Cancer Research
    • Place of Presentation
      鹿児島大学(鹿児島)
    • Year and Date
      2013-02-16
  • [Presentation] 前立腺癌薬物療法、今後の展開2013

    • Author(s)
      上村博司
    • Organizer
      前立腺癌 Expert Meeting Sat
    • Place of Presentation
      ホテルニューオータニ(東京)
    • Year and Date
      2013-02-09
  • [Presentation] Safety and efficacy of docetaxel in prostate cancer patients: based on th post-marketing suveillance in Japan2012

    • Author(s)
      H Uemura
    • Organizer
      Asia-Pacific genitourinary conference
    • Place of Presentation
      台北(台湾)
    • Year and Date
      20120612-13
  • [Presentation] 前立腺癌薬物治療の新戦略2012

    • Author(s)
      上村博司
    • Organizer
      第56回 TEUS(Tokyo Expert Urology Seminar)
    • Place of Presentation
      東京ドームホテル(東京)
    • Year and Date
      2012-12-03
  • [Presentation] Possibility an limitation of androgen receptor as molecular target for prostate cancer2012

    • Author(s)
      H Uemura, Y Itoh, Y Kubota
    • Organizer
      15th International Congress on Hormone Steroids and Hormone & Cancer, Symposium 8, Prostate cancer, Invited
    • Place of Presentation
      石川県立音楽堂(石川県)
    • Year and Date
      2012-11-17
  • [Presentation] 限局性前立腺癌に対する放射線治療について、イブニングセミナー、「限局性前立腺癌に対する治療選択」2012

    • Author(s)
      上村博司
    • Organizer
      第62回日本泌尿器科学会中部総会
    • Place of Presentation
      富山国際会議場(富山県)
    • Year and Date
      2012-11-02
  • [Presentation] 去勢抵抗性前立腺癌の話題「去勢抵抗性前立腺癌-治療の現状と分子メカニズム」2012

    • Author(s)
      上村博司
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2012-10-27
  • [Presentation] ハイリスク前立腺癌の治療戦略、症例検討パネルディスカッション2012

    • Author(s)
      上村博司
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2012-10-25
  • [Presentation] 前立腺癌の画像診断と PSA2012

    • Author(s)
      上村博司
    • Organizer
      日本臨床検査自動化学会第44回大会、インテグレーションセミナー
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2012-10-13
  • [Presentation] 我が国における去勢抵抗性前立腺癌の現状2012

    • Author(s)
      上村博司
    • Organizer
      第19回東京前立腺癌フォーラム、シンポジウム
    • Place of Presentation
      丸ビル(東京)
    • Year and Date
      2012-10-06
  • [Presentation] Regulation of androgen receptor by angiotensin1-7 in prostate cancer cells2012

    • Author(s)
      上村博司、伊藤悠亮、石黒斉、窪田吉信
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-21
  • [Presentation] これから期待される前立腺癌内分泌治療薬2012

    • Author(s)
      上村博司
    • Organizer
      第9回日本臨床泌尿器科医会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2012-07-18
  • [Presentation] アンジオテンシンIIレセプターブロッカーの前立腺癌発生予防の実験的検証2012

    • Author(s)
      上村博司、伊藤悠亮、星野耕二、高橋智、窪田吉信
    • Organizer
      第21回日本腎泌尿器疾患予防医学研究会
    • Place of Presentation
      高知文化プラザ(高知県)
    • Year and Date
      2012-07-13
  • [Presentation] 治療法から見た去勢抵抗性前立腺癌の進展とその対策2012

    • Author(s)
      上村博司
    • Organizer
      第25回日本老年泌尿器科学会イブニングセミナー
    • Place of Presentation
      あわぎんホール(徳島県)
    • Year and Date
      2012-06-01
  • [Presentation] Answer to case discussion2, Case discussion 2 "Castration-resistant prostate cancer-CRPC"2012

    • Author(s)
      H Uemura
    • Organizer
      The 7thAUA/JUA International Affiliate Society Meeting
    • Place of Presentation
      アトランタ、(米国)
    • Year and Date
      2012-05-20
  • [Presentation] Usefulness of Contrast Enhanced Ultrasound in Imaging and Detection of Prostate Cancer, Symposium "Genitourinary"2012

    • Author(s)
      H Uemura
    • Organizer
      The 4thAsian Conference on Ultrasound Contrast Imaging
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2012-05-13
  • [Presentation] 去勢抵抗性前立腺癌に対するアンドロゲンレセプターの標的分子としての可能性と限界2012

    • Author(s)
      上村博司
    • Organizer
      第100回日本泌尿器科学会総会シンポジウム「前立腺癌の内分泌治療の新しい展開」
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2012-04-22
  • [Presentation] 去勢抵抗性前立腺癌に対する新規ホルモン療法について2011

    • Author(s)
      上村博司
    • Organizer
      Urology Seminar
    • Place of Presentation
      帝国ホテル(東京)
    • Year and Date
      2011-11-25
  • [Presentation] 前立腺癌の新たな治療の探索、教育講演2011

    • Author(s)
      上村博司
    • Organizer
      第76回日本泌尿器科学会東部総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-10-21
  • [Presentation] ANGIOTENSIN II RECEPTOR BLOCKER HAS THE POTENTIAL TO SUPPRESS PSA FAILURE AFTER PROSTATECTOMY2011

    • Author(s)
      Hiroji Uemura, Narihiko Hayashi, Futoshi Sano, Hitoshi Ishiguro, Kouji Hoshino, Yasuhide Miyoshi, Jun-ichi Teranishi, Kazumi Noguchi, YoshinobuKubota
    • Organizer
      アメリカ泌尿器科学会総会
    • Place of Presentation
      米国ワシントンDC
    • Year and Date
      2011-05-16
  • [Presentation] 去勢抵抗性前立腺癌の新しい標的分子と臨床への応用について、シンポジウム:前立腺癌研究の最新の進歩:基礎研究から臨床に向けて2011

    • Author(s)
      上村博司
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-04-21
  • [Presentation] リスク分類に基づいた早期癌の治療戦略、パネルディスカッション「早期前立腺癌の治療戦略」2010

    • Author(s)
      上村博司
    • Organizer
      第48回日本癌治療学会総会
    • Place of Presentation
      国立京都国際会議場(京都)
    • Year and Date
      2010-10-30
  • [Presentation] Role of Renin-Angiotensin System in Prostate Cancer, Symposium "Angiotensin"2010

    • Author(s)
      Hiroji Uemura, Satoru Takahashi, Kouji Hoshino, Hitoshi Ishiguro, Yoshinobu Kubota
    • Organizer
      14thInternational Congress on Hormone Steroids and Hormones & Cancer
    • Place of Presentation
      エンジンバラ、英国
    • Year and Date
      2010-09-22
  • [Presentation] 前立腺癌におけるレニン-アンジオテンシン系の役割2010

    • Author(s)
      上村博司
    • Organizer
      第3回前立腺生物学シンポジウム伊勢志摩
    • Place of Presentation
      鳥羽国際ホテル(三重県)
    • Year and Date
      2010-06-18

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Published: 2014-08-29  

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