Mechanism of protective effects of atrial natriuretic peptide on acute kidney injury

2014 Fiscal Year Final Research Report

• Project/Area Number: 22592010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MITAKA Chieko 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (20126254)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 急性腎傷害 / 心房性ナトリウム利尿ペプチド / サイトカイン / 炎症 / 虚血再灌流傷害 / 造影剤

Outline of Final Research Achievements

We investigated whether atrial natriuretic peptide (ANP) attenuates renal ischemia-reperfusion injury (IRI)-induced acute kidney injury (AKI) or contrast-induced AKI. ANP prevented renal IRI-induced metabolic acidosis, pulmonary edema, increased plasma concentrations of lactate, creatinine and potassium in rats. In addition, ANP attenuated renal IRI-induced increases in plasma concentrations of IL-1beta and IL-6 as well as elevation of TNF-alpha, IL-1beta, IL-6 mRNA and TNF-alpha, IL-6, NF-kappaB protein expressions in kidney and lung. These findings suggest that ANP prevents kidney-lung cross talk by inhibiting inflammatory cytokines in rat renal IRI model. Furthermore, pretreatment of ANP attenuated contrast-induced AKI in rats.

Free Research Field

敗血症、急性腎傷害