2011 Fiscal Year Final Research Report
The research of the drugs that can promote SOX9m RNA expression in chondrocyte
| Project/Area Number |
22659269
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
ISHIGURO Naoki 名古屋大学, 大学院・医学系研究科, 教授 (20212871)
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| Co-Investigator(Kenkyū-buntansha) |
KITOH Hiroshi 名古屋大学, 医学部附属病院, 講師 (40291174)
SAKAI Tadahiro 名古屋大学, 医学部附属病院, 病院講師 (60378198)
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| Project Period (FY) |
2010 – 2011
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| Keywords | SOX9 / Runx2 / BMP / 骨芽細胞分化 |
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| Research Abstract |
We successfully found out two drugs that could up-regulate mRNA expression of SOX9. However, these two drugs showed only the limited effects on the metabolism of native chondrocytes. We could not achieve stable results with these two substances. We decided to repeat the drug screening again. According to the back up experiment concerning RUNX2, two drugs were identified. These two drugs up-regulate mRNA expression of ALP and osteocalcin with modification of the non-canonical pathway of BMP signal. We started the new experiment concerning newly bone formation with these drugs in animal model.
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[Journal Article] Study protocol of a multicenter registry of patients with rheumatoid arthritis starting biologic therapy in Japan : Tsurumai Biologics Communication Registry(TBCR) Study2011
Author(s)
Kojima T, Kaneko A, Hirano Y, Ishikawa H, Miyake H, Oguchi T, Takagi H, Yabe Y, Kato T, Ito T, Terabe K, Fukaya N, Kanayama Y, Shioura T, Funahashi K, Hayashi M, Kato D, Matsubara H, Fujibayashi T, Kojima M, Ishiguro N.
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Journal Title
Mod Rheumatol
Volume: (in press)
Peer Reviewed
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[Journal Article] Early aggressive intervention with tocilizumab for rheumatoid arthritis increases remission rate defined using a Boolean approach in clinical practice2011
Author(s)
Kojima T, Kaneko A, Hirano Y, Ishikawa H, Miyake H, Takagi H, Yabe Y, Kato T, Terabe K, Fukaya N, Tsuchiya H, Shioura T, Funahashi K, Hayashi M, Kato D, Matsubara H, Ishiguro N.
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Journal Title
Mod Rheumatol
Volume: (in press)
Peer Reviewed
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[Journal Article] Novel and recurrent TRPV4 mutations and their association with distinct phenotypes within theTRPV4 dysplasia family2010
Author(s)
Dai J, Kim OH, Cho TJ, Schmidt-Rimpler M, Tonoki H, Takikawa K, Haga N, Miyoshi K, Kitoh H, Yoo WJ, Choi IH, Song HR, Jin DK, Kim HT, Kamasaki H, Bianchi P, Grigelioniene G, Nampoothiri S, Minagawa M, Miyagawa S, Fukao T, Marcelis C, Jansweijer MCE, Hennekam RCM, Bedeschi F, Mustonen A, Jiang Q, Ohashi H, Furuichi T, Unger S, Zabel B, Lausch E, Superti-Furga A, Nishimura N, Ikegawa S.
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Journal Title
J Med Genet
Volume: 47(10)
Pages: 704-709
Peer Reviewed
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[Journal Article] Spondylo-epiphyseal dysplasia, Maroteaux type(pseudo-Morquiosyndrome type 2) and parastremmatic dysplasia are caused by TRPV4 mutations2010
Author(s)
Nishimura G, Dai J, Lausch E, Unger S, Megarbane A, Kitoh H, OH Kim, Cho TJ, Bedeschi F, Benedicenti F, Mendoza-Londono R, Silengo M, Schmidt-Rimpler M, Spranger J, Zabe lB, Ikegawa S, Superti-Furga A.
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Journal Title
Am J Med Genet
Volume: 152A(6)
Pages: 1443-1449
Peer Reviewed
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