2013 Fiscal Year Final Research Report
Pathophysiological role of the blood-brain barrier hemichannels and molecular-targeted diagnosis and therapy
| Project/Area Number |
22689005
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University (2011-2013)
University of Toyama (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | ヘミチャネル / 脳毛細血管内皮細胞 / パネキシン / コネキシン / 輸送 / 血液脳関門 |
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| Research Abstract |
The present findings have established the new concept that specific subtypes of hemichannels, i.e., pannexin 1 and connexin 43, at the human blood-brain barrier (BBB) make a significant contribution to the dysfunction of the BBB transport system under acute ischemic conditions. This could raise the potential of the BBB hemichannels as a therapeutic target for brain ischemic damage exaggeration.
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Research Products
(40 results)
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[Journal Article] A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice2013
Author(s)
Uchida Y, Tachikawa M, Obuchi W, Hoshi Y, Tomioka Y, Ohtsuki S, Terasaki T
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Journal Title
Fluids Barriers CNS
Volume: 10(1)
Pages: 21
Peer Reviewed
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[Journal Article] Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood-Brain Barrier Model2013
Author(s)
Ohtsuki S, Ikeda C, Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, Kubo Y, Tachikawa M, Terasaki T
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Journal Title
Mol Pharm
Volume: 10
Pages: 289-296
Peer Reviewed
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[Journal Article] A clearance system for prostaglandin D2, a sleep-promoting factor, in the cerebrospinal fluid : role of the blood-cerebrospinal barrier transporters2012
Author(s)
Tachikawa M, Tsuji K, Yokoyama R, Higuchi T, Ozeki G, Yashiki A, Akanuma S, Hayashi K, Nishiura A, Hosoya K
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Journal Title
J Pharmacol Exp Ther
Volume: 343
Pages: 608-616
Peer Reviewed
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[Journal Article] Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier2011
Author(s)
Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T
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Journal Title
J Neurochem
Volume: 118
Pages: 407-415
Peer Reviewed
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