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2011 Fiscal Year Final Research Report

Detection of a defense system of intestinal mucosa as a novel examination tool for canine inflammatory bowel disease

Research Project

  • PDF
Project/Area Number 22780279
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Clinical veterinary science
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

IDE Kaori  東京農工大学, 大学院・農学研究院, 助教 (40550281)

Project Period (FY) 2010 – 2011
Keywords犬 / 炎症性腸疾患 / 腸管型アルカリフォスファターゼ / 腸管粘膜上皮
Research Abstract

Intestinal alkaline phosphatase (iALP) was found to be expressed with enzymatic activity, more intensively in mucosal epithelia of duodenum than of colon, in dogs. Dephosphorylation reaction of lipopolysaccharide (LPS), which is the core function of the defense mechanism by iALP against excessive intestinal microflora, was also proven to be active. Fecal iALP concentration was shown to be high in cases of severe inflammatory bowel disease with high clinical activity score.

  • Research Products

    (2 results)

All 2012 Other

All Presentation (1 results) Remarks (1 results)

  • [Presentation] 犬の腸管型アルカリフォスファターゼに関する検討2012

    • Author(s)
      井手香織、岩崎望、松本英、平塚彰悟、石下進平、西藤公司、岩崎利郎
    • Organizer
      日本獣医内科学アカデミー学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2012-02-18
  • [Remarks]

    • URL

      http://www.tuat-amc.org/laboratory/

URL: 

Published: 2015-03-12  

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