2012 Fiscal Year Final Research Report
Pathophysiological relationship ofmitochondria to neuronal death during brain ischemia
| Project/Area Number |
22790256
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
KANBE Yuki 鹿児島大学, 大学院・医歯学総合研究科, 助教 (60549913)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 神経細胞死 / 細胞内情報伝達 / ミトコンドリア |
|---|
| Research Abstract |
Pituitary adenylate cyclase-activating polypeptide (PACAP) increases neurite outgrowth in many kind of neuronal cells, but signaling via its receptor PACAP-specific receptor has not been fully characterized. Because mitochondria also play an important role in neurodevelopment including dendritic branching, axonal guidanceand neurite outgrowth, we examined whether mitochondria contribute to PACAP-mediated neurite outgrowth. Present data suggest that mitochondrial activation plays a key role in PACAP-induced neurite outgrowth via a signaling pathway that includes PAC1R, PKA, andPgc1α.
|
