2013 Fiscal Year Final Research Report
Analysis of human Th17/Th21 cells in allergy and autoimmune diseases
| Project/Area Number |
22790940
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saitama Medical University |
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Principal Investigator |
TAKAGI Rie 埼玉医科大学, 医学部, 助手 (00569080)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | アレルギー学 |
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| Research Abstract |
Allergic airway inflammation is generally considered to be a Th2-type immune response. Recent studies, however, have demonstrated that Th17-type immune responses also play important roles in this process, particularly in the pathogenesis of neutrophilic airway inflammation, a hallmark of severe asthma. We therefore evaluated whether wogonin suppresses OVA-induced neutrophilic airway inflammation in OVA TCR-transgenic DO11.10 mice. Consequently, oral administrationof wogonin significantly improved OVA-induced neutrophilic airway inflammation. Wogonin suppressed the differentiation of naive T cells to Th17 cells, while showing no effects on activated Th17 cells.
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[Journal Article] Coenzyme A contained in mothers' milk is associated with the potential to induce atopic dermatitis2011
Author(s)
Higashi, T., Shimojo, N., Suzuki, S., Nakaya, M., Takagi, R., Hashimoto, K., Nakagome, K., Nakamura, K., Kohno, Y. and Matsushita, S.
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Journal Title
Int. Immunol
Volume: 23
Pages: 741-749
Peer Reviewed
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[Journal Article] Wogonin attenuates ovalbumin antigen-induced neutrophilic airway inflammation by inhibiting Th17 differentiation
Author(s)
Takagi, R., Kawano, M., Nakagome, K., Hashimoto, K., Higashi, T., Ohbuchi, K., Kaneko, A. and Matsushita, S.
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Journal Title
Int. J. Inflamm.
Volume: (in press)
Peer Reviewed
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