2011 Fiscal Year Final Research Report
Control of kidney fibrosis in the mouse unilateral urethral obstruction model with the novel AP-1 inhibitor
| Project/Area Number |
22791499
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 水腎症 / 線維化 |
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| Research Abstract |
The unilateral ureteral obstructive(UUO) model of the mouse was created. We evaluated the natural time course of renal fibrosis after UUO operation. Renal fibrosis was occurred in both renal medulla and cortex at least from the 3rd day after UUO creation. DHMEQ treatment decreased the interstitial fibrosis, tubular apoptosis and proliferation as compared with control group in the non-immune nephritis model. On the other hand, DTCM(dodecylthiocarbonyl methyl) did not achieve the significant effect against the renal fibrosis compared with the control group. I thought that the further detailed examination of the medication method, an administration route, and a dosing period was required.
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