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2023 Fiscal Year Final Research Report

MHC dressing via trogocytosis

Research Project

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Project/Area Number 22K19391
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 47:Pharmaceutical sciences and related fields
Research InstitutionRitsumeikan University

Principal Investigator

Masafumi Nakayama  立命館大学, 薬学部, 教授 (20453582)

Project Period (FY) 2022-06-30 – 2024-03-31
Keywordsトロゴサイトーシス / 樹状細胞 / MHCクラスI / 抗原提示
Outline of Final Research Achievements

Trogocytosis is an active process whereby plasma membrane proteins are transferred from one cell to the other cell in a cell-cell contact-dependent manner. Conventional dendritic cells (DCs) reportedly acquire MHC class I (MHCI) via trogocytosis and subsequently prime CD8+ T cells via the pre-formed antigen-MHCI complexes without antigen processing. However, this mechanism is not fully understood. Here, we demonstrate that DCs rapidly acquire MHCI-containing membrane fragments from dead cells via the phosphatidylserine recognition-dependent mechanism. The MHCI dressing is enhanced by a TLR3 ligand polyinosinic-polycytidylic acid (polyI:C). These results suggest that trogocytosis-mediated MHCI dressing is involved in inflammatory diseases associated with cell death and type I IFN production.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

本研究成果により、MHC クラスI分子を身に纏った(ドレス化)樹状細胞による新しい細胞性免疫誘導メカニズムが明らかとなった。このMHCクラスI分子のドレス化を自在にコントロールする方法が開発できれば、それを正に調節することによって、がんやウイルス感染に対する防御機能を高めることに繋がり、逆に負に調節すれば、自己免疫疾患の発症抑制に繋がることが期待される。

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Published: 2025-01-30  

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