Elucidation of Inflammatory disorder induced by intestinal dysbiosis

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K19445
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 49:Pathology, infection/immunology, and related fields
• Research Institution: Keio University
• Principal Investigator: Hase Koji 慶應義塾大学, 薬学部(芝共立), 教授 (20359714)
• Project Period (FY): 2022-06-30 – 2024-03-31
• Keywords: 腸内細菌 / 粘膜バリア

Outline of Final Research Achievements

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are rare and intractable diseases of unknown cause. IBD patients show abnormalities in the intestinal microbiota, termed dysibiosis. Therefore, dysbiosis has been considered a factor that exacerbates the disease, but its pathological mechanism has remained unresolved for many years. The applicant has found that mice of the same strain shipped from different breeding facilities show different susceptibilities to colitis. In this study, we focused on differences in the intestinal microbiota due to the growth environment and examined the impact of dysbiosis on colitis susceptibility. As a result, it was found that mice from breeding facilities with high susceptibility to colitis had bacterial species that impair barrier function.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

IBDとディスバイオーシスの相関については数多くの研究が存在するが、その多くは現象論に留まっており、その因果関係や病態メカニズムの解明には至っていない。本研究では、疾患関連菌として未知のバリア分解菌に着目し、その絞り込みに成功しており、ディスバイオーシスによる腸炎悪化のメカニズムの解明に繋がることが期待できる。