Development of On-Demand Acid/Base Catalysis Enabled by Single-Electron Oxidation/Reduction

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20546
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0501:Physical chemistry, functional solid state chemistry, organic chemistry, polymers, organic materials, biomolecular chemistry, and related fields
• Research Institution: Kobe Pharmaceutical University
• Principal Investigator: Hirata Tsubasa 神戸薬科大学, 薬学部, 助教 (30962641)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 触媒 / 酸化 / 還元 / 酸 / 塩基 / 光触媒 / 付加反応 / 位置選択性

Outline of Final Research Achievements

Photoredox catalysts have a feature that they can catalyze both oxidation and reduction in the same reaction system, and a variety of photocatalytic reactions have been developed recently. In this research, we have developed a novel catalytic system that properly adjusts the redox potentials to efficiently promote the desired reactions. Particularly, Lewis acids, which make the photoredox catalysts and substrates electron-deficient, were used as a co-catalyst, and it was revealed that the catalytic system could be applied for the acceleration of photocatalytic reactions and strictly controlling the regioselectivity of addition reactions.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

本研究では、ルイス酸を共触媒として用いることで、目的の反応に適した酸化還元電位をコントロールし、光酸化還元触媒や基質の酸化力および還元力をin situで制御できることを見出した。さらに、このような触媒システムによって、反応加速や選択性の制御が可能であるという知見を得た。本研究で見出すことのできた触媒システムは、光酸化還元反応における反応制御のための新たな手法になると期待できる。