2023 Fiscal Year Final Research Report
Elucidation of the Role of Mitochondrial Dynamics in Tracheal Stem Cells
| Project/Area Number |
22K20654
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0702:Biology at cellular to organismal levels, and related fields
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Keywords | ミトコンドリア / 幹細胞 / シグナル |
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| Outline of Final Research Achievements |
The study aimed to elucidate the molecular mechanisms by which the mitochondrial shaping factor OPA1 regulates respiratory stem cells. As a result, we identified epigenetic changes due to OPA1 deficiency and found a positional correlation between ciliary structures and mitochondria. Additionally, we discovered that mitochondrial inner membrane factors are crucial for alveolar morphogenesis. Our findings were presented at domestic and international conferences, particularly receiving the Outstanding Presentation Award at the Symposium on Biological Functions and Drug Discovery 2023. Furthermore, we demonstrated the involvement of OPA1 in EGFR inhibitor resistance in lung adenocarcinoma, publishing our findings in Cell Death & Disease (2023), thereby highlighting the significance of OPA1 in the respiratory epithelium
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、組織幹細胞におけるミトコンドリア機能の分子メカニズムを明らかにすることで、ミトコンドリアを標的とした組織幹細胞制御による組織再生促進医療の開発へと波及する可能性を秘めている。本成果で示唆されるミトコンドリア融合因子による呼吸器幹細胞の染色体修飾制御機構は、そのメカニズムの一端を明らかにしたものと考えられ、同作用点に注目した幹細胞制御法の確立に向けて前進したと考えられる。また、ミトコンドリアと線毛形成機構の位置的関与という細胞生物学分野における将来的な学術的新展開に貢献する可能性を示している。
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