2023 Fiscal Year Final Research Report
Investigation of the Role of TRPV3 Channels in the Heat Dissipation Response in Humans: Toward the Establishment of Heat Stroke Prevention Strategies
| Project/Area Number |
22K21198
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0909:Sports sciences, physical education, health sciences, and related fields
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Keywords | 運動生理学 / 体温調節機能 / TRPV3 / スポーツ科学 |
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| Outline of Final Research Achievements |
In this study, we examined whether application of the TRPV3 channel agonist carvacrol (an essential oil component of oregano) to human skin causes TRPV3 channel-derived cutaneous vasodilation and investigated the mechanism of cutaneous vasodilation induced by application of carvacrol. The results showed that nitric oxide synthase, cyclooxygenase, and potassium channels were partially involved in TRPV3 channel-derived cutaneous vasodilation induced by carvacrol application. The results obtained in this study were presented orally at the 2023 meeting of the Japanese Society for Biometeorology.
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| Free Research Field |
運動生理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によって得られた知見は、暑熱下運動時の熱中症予防策の確立に貢献する可能性がある。暑熱下運動時には体温調節反応である発汗と皮膚血管拡張によって過度の深部体温上昇を抑制している。そのため、この体温調節反応を向上させることができれば、過度の深部体温上昇に起因する熱中症発生リスクを低減できる可能性がある。本研究では、カルバクロール塗布によってTRPV3由来の皮膚血管拡張が起こることを示唆しており、この研究が発展していくことで暑熱下運動時の体温調節反応を高める新たな方策の開発に繋がるかもしれない。
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