Development of a tailor-made molecular targeted oncologic diagnostic imaging using a newly-developed amino acid PET tracer.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23300360
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor diagnosis
• Research Institution: Research Institute, Shiga Medical Center
• Principal Investigator: HIGASHI Tatsuya 滋賀県立成人病センター(研究所), その他部局等, その他 (50324629)
• Co-Investigator(Kenkyū-buntansha): NISHII Ryuichi 宮崎大学, 医学部, 講師 (60463212) ; KAGAWA Shinya 滋賀県立成人病センター(研究所), 主任研究員 (10393191) ; OOMOMO Yoshiro 大阪薬科大学, 薬学部, 准教授 (70183241)
• Project Period (FY): 2011-11-18 – 2014-03-31
• Keywords: 癌 / 放射線画像診断 / 薬学 / テーラーメード治療 / 分子標的

Research Abstract

We developed and had a success of the radio-synthesis method of [18F]NMeFAMP and the results of the synthesis was quite excellent with yield evaluation about 20%, synthesis time about 90 min, radiochemical purity > 99.9%. However, we could not move ahead to quality control test, acute toxicity test, etc. On the other hand, we had successful results in the radio-synthesis methods of [18F]FACE using newly-introduced solid phase extraction techniques, two-pot distillation and one-pot distillation methods. With these techniques, we can provide [18F]FACE radio-synthesis methods with higher quality, cheaper, and more simple process, as compared to the traditional on-column hydrolysis method. After the approval of our ethical committee, we performed a human PET study with liver tumor patients using [18F]FACE and [18F]FDG, and the results were published by a well-known medical journal, Annals of Nuclear Medicine.

Research Products

• [Journal Article] Assessment of [18F]-fluoroacetate PET/CT as a tumor-imaging modality : preclinical study in healthy volunteers and clinical evaluation in patients with liver tumor (2014)
  • Author(s): Takemoto K, Hatano E, Nishii R, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Matsumura K, Zaima M, Toriguchi K, Tanabe K, Kitamura K, Seo S, Taura K, Endo K, Uemoto S, Higashi T
  • Journal Title: Ann Nucl Med Volume: (Epub ahead of print)
• [Journal Article] Diagnostic usefulness of an amino acid tracer, α-[N-methyl- ^11C]-methylaminoisobutyric acid ( ^<11>C-MeAIB), in the PET diagnosis of chest malignancies (2013)
  • Author(s): Nishii R, Higashi T, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Motoyama H, Kawakami K, Nakaoku T, Nohara J, Okamura M, Watanabe T, Nakatani K, Nagamachi S, Tamura S, Kawai K, Kobayashi M
  • Journal Title: Ann Nucl Med Volume: 27(9) Pages: 808-21
  • DOI: 10.1007/s12149-013-0750-4.Epub2013Jul4
• [Presentation] Novel approach for solid-phase radiosynthesis of ^<18>F-Fluoroacetate : Comparison between one-pot and two-pot distillation procedure (2013)
  • Author(s): Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Kenji Takemoto, Akiko Tachibana, Kazuhiro Takahashi, Hiroshi Mizuma, Hirotaka Onoe, Keiichi Kawai
  • Organizer: The Society of Nuclear Medicine and Molecular Imaging (SNMMI) 60th Annual Meeting
  • Place of Presentation: VANCOUVER, BC, CANADA
  • Year and Date: 20130608-12
• [Presentation] Radiosynthesis of [^<18>F]Fluoroacetate by a one-pot distillation procedure : a novel approach of the solid-phase synthesis (2013)
  • Author(s): Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Kenji Takemoto, Etsuro Hatano, Akiko Tachibana, Kazuhiro Takahashi, Hiroshi Mizuma, Hirotaka Onoe, Shigeki Nagamachi, Keiichi Kawai, Shozo Tamura
  • Organizer: The 20th International Symposium on Radiopharmaceutical Sciences (ISRS)
  • Place of Presentation: ICC JEJU, Jeju, KOREA
  • Year and Date: 20130512-17
• [Presentation] 新しい固相抽出技術を用いた[^<18>F]Fluoroacetate ([^<18>F]FACE) 合成法の検討 (2013)
  • Author(s): 加川信也, 西井龍一, 東達也, 山内 浩, 高橋和弘, 水間広, 尾上浩隆, 竹本研史, 波多野悦郎, 川井恵一
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡国際会議場, 博多, 福岡
  • Year and Date: 2013-11-09
• [Presentation] Oncologic diagnosis of liver tumors using [^<18>F]-fluoroacetate PET/CT as compared to [^<18>F]-fluorodeoxyglucose PET/CT (2013)
  • Author(s): Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Kazuyoshi Matsumura, Masazumi Zaima, Kenji Takemoto, Etsuro Hatano
  • Organizer: Initial experience. EANM2013. Annual Congress of the European Association of Nuclear Medicine
  • Place of Presentation: Lyon, France
  • Year and Date: 2013-10-19
• [Presentation] [^<18>F]Fluoroacetate ([18F]FACE) 臨床研究に向けて (2013)
  • Author(s): 加川 信也, 矢倉 栄幸, 西井 龍一, 東 達也, 岸辺 喜彦, 高橋 昌章, 山内 浩, 水川 陽介, 竹本 研史, 波多野 悦郎, 高橋 和弘, 水間 広, 尾上 浩隆, 川井 恵一
  • Organizer: PETサマーセミナー2013
  • Place of Presentation: 金沢日航ホテル, 金沢, 石川
  • Year and Date: 2013-08-23
• [Presentation] 腫瘍PET診断-post-FDGの将来展望- (2013)
  • Author(s): 東 達也
  • Organizer: 横浜市立大学・群馬大学放射線診断核医学講座共催 第2回YG Conference( 特別講演 )
  • Place of Presentation: ニューサンピア高崎, 高崎, 群馬
  • Year and Date: 2013-08-03
• [Presentation] Assessment of [^<18>F]-Fluoroacetate PET/CT as a tumor-imaging modality : Comparison with [^<18>F]-FDG in patients with liver tumor and in healthy volunteers (2013)
  • Author(s): Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Kazuyoshi Matsumura, Masazumi Zaima, Kenji Takemoto, Etsuro Hatano
  • Organizer: 60th Annual Meeting of Society of Nuclear Medicine
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2013-06-08
• [Presentation] 核医学診断・治療の臨床 現状と展望 (2013)
  • Author(s): 東 達也
  • Organizer: 神戸薬科大学特別研究セミナー(教育講演)
  • Place of Presentation: 神戸薬科大学, 神戸市, 兵庫
  • Year and Date: 2013-03-07
• [Presentation] PET 薬剤合成の勘所 : [^<18>F] フルオロ酢酸 (2013)
  • Author(s): 加川信也
  • Organizer: PET化学ワークショップ2013 (シンポジスト)
  • Place of Presentation: 由布院,大分県
  • Year and Date: 2013-02-09
• [Presentation] 臨床使用に向けた[^<18>F]Fluoroacetate ([^<18>F]FACE )製造法の検討 (2012)
  • Author(s): 加川信也, 矢倉栄幸, 西井龍一, 東達也, 山内浩, 水川陽介, 竹本研史, 波多野悦郎, 高橋和弘, 水間広, 尾上浩隆, 長町茂樹, 川井恵一, 田村正三
  • Organizer: 第七回日本分子イメージング学会
  • Place of Presentation: アクトシティ浜松, 浜松, 静岡
  • Year and Date: 20120524-25
• [Presentation] Radiosynthesis of [^<18>F]Fluoroacetate : Comparison between on-column hydrolysis method and two-pot distillation procedure using a cassette-type multipurpose automatic synthesizer module (2012)
  • Author(s): Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroyo Araki, Hiroyuki Okudaira, Tomoya Uehara, Masato Kobayashi, Mitsuyoshi Yoshimoto, Yasushi Arano, Keiichi Kawai
  • Organizer: European Association of Nuclear Medicine ( EANM ) Congress 2012
  • Place of Presentation: Milan, Italia
  • Year and Date: 2012-10-30
• [Presentation] [^<18>F]Fluoroacetateの合成法の開発 : オンカラム加水分解法とtwo-pot蒸留法の比較 (2012)
  • Author(s): 加川信也, 西井龍一, 東達也, 岸辺喜彦, 高橋昌章, 高橋和弘, 水間広, 尾上浩隆, 竹本研史, 川井恵一, 山内浩
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: ロイトン札幌, 札幌市, 北海道
  • Year and Date: 2012-10-12
• [Presentation] アミノ酸ポジトロン製剤MeAIBによる前立腺癌PET診断-FDG, MRI との比較検討- (2012)
  • Author(s): 東達也, 西井龍一, 加川信也, 岸辺喜彦, 高橋昌章, 山内浩, 石戸谷哲, 植村祐一, 牛田博, 大西裕之
  • Organizer: 第52回日本核医学会 学術総会
  • Place of Presentation: ロイトン札幌, 札幌市, 北海道
  • Year and Date: 2012-10-11
• [Presentation] アミノ酸ポジトロン製剤 MeAIB を用いた胸部腫瘍 PET 診断 (2012)
  • Author(s): 東達也, 西井龍一, 加川信也, 岸辺喜彦, 高橋昌章, 山内浩
  • Organizer: 第52回日本核医学会 学術総会
  • Place of Presentation: ロイトン札幌, 札幌市, 北海道
  • Year and Date: 2012-10-11
• [Presentation] がん診療におけるPETの現状と将来展望 (2012)
  • Author(s): 東 達也
  • Organizer: 滋賀県立成人病センター第3回がん診療グランドセミナー(教育講演)
  • Place of Presentation: 滋賀県立成人病センター研究所講堂, 守山, 滋賀
  • Year and Date: 2012-09-29
• [Presentation] アミノ酸ポジトロン製剤MeAIBを用いた胸部腫瘍PET診断の経験 (2012)
  • Author(s): 東達也, 西井龍一, 加川信也, 岸辺喜彦, 高橋昌章
  • Organizer: 第45回日本核医学会近畿地方会
  • Place of Presentation: メルパルク京都, 京都
  • Year and Date: 2012-07-28
• [Presentation] 腫瘍 PET と核医学治療-overview- (2012)
  • Author(s): 東 達也
  • Organizer: 群馬大学放射線診断核医学講座 第257回Open Film Conference( 特別講演 )
  • Place of Presentation: 群馬大学医学部臨床中講堂, 前橋, 群馬
  • Year and Date: 2012-07-26
• [Presentation] Assessment of efficacy of [^<11>C]-MeAIB PET/CT as a biomarker of the system A amino acid transport : Comparison with [^<18>F]-FDG and MRI in the patients with prostate cancer (2012)
  • Author(s): Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Satoshi Ishitoya, Hiroshi Ushida, Yuichi Uemura, Hiroyuki Oonishi, Keiichi Kawai, Masato Kobayashi
  • Organizer: 59th Annual Meeting of Society of Nuclear Medicine
  • Place of Presentation: Miami, Florida, USA
  • Year and Date: 2012-06-09
• [Presentation] 新規アミノ酸ポジトロン製剤MeAIBによる縦隔腫瘍PET診断 (2012)
  • Author(s): 東達也, 加川信也, 法幸由起子, 川上賢三, 中奥敬史, 野原淳, 渡辺寿規, 中谷光一
  • Organizer: 第4回呼吸機能イメージング研究会学術集会
  • Place of Presentation: プラザ淡海, 大津市, 滋賀
  • Year and Date: 2012-02-11
• [Presentation] 新規アミノ酸ポジトロン製剤 MeAIB による前立腺癌 PET 診断 -FDG, MRI との比較検討による中間報告 - (2011)
  • Author(s): 東達也, 加川信也, 岸辺喜彦, 高橋昌章, 山内浩, 石戸谷哲, 植村祐一, 大西裕之, 南俊介, 西井龍一, 川井恵一
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場, つくば, 茨城
  • Year and Date: 2011-10-28
• [Presentation] PET腫瘍診断薬 [^<18>F]Fluoroacetate の合成基礎検討 (2011)
  • Author(s): 加川信也, 西井龍一, 東達也, 岸辺喜彦, 高橋昌章, 山内浩, 竹本研史, 波多野悦郎, 長町茂樹, 川井恵一, 田村正三
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば国際会議場, つくば, 茨城
  • Year and Date: 2011-10-28
• [Presentation] 肝胆膵疾患における腫瘍 PET 診断 (2011)
  • Author(s): 東 達也,波多野悦朗
  • Organizer: 第9回日本消化器外科学会大会 第82回日本消化器内視鏡学会総会 第19回日本消化器関連学会週間DDWJapan2011 ( 教育講演 )
  • Place of Presentation: 福岡国際センター, 博多, 福岡
  • Year and Date: 2011-10-22
• [Presentation] Usefulness of Double Tracer PET study using [^<18>F]FDG and Amino Acid Radiotracer, [^<11>C]MeAIB, in the Diagnosis of Mediastinal Diseases (2011)
  • Author(s): Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe,Keiichi Kawai, Masato Kobayashi
  • Organizer: 58th Annual Meeting of Society of Nuclear Medicine
  • Place of Presentation: San Antonio, USA
  • Year and Date: 2011-06-06
• [Presentation] F-18フルオロ酢酸のヒト肝細胞における集積検討 (2011)
  • Author(s): 加川信也, 西井龍一, 竹本研史, 東達也, 波多野悦郎, 水間広, 尾上浩隆, 長町茂樹, 川井恵一, 田村正三, Juri G Gerovani
  • Organizer: 第六回日本分子イメージング学会
  • Place of Presentation: 神戸国際会議場, 兵庫
  • Year and Date: 2011-05-26
• [Remarks]
  • URL: http://www.shigamed.jp/