2014 Fiscal Year Final Research Report
Systems engineering approach for colitis remission by use of gut commensal bacteria
| Project/Area Number |
23360373
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OSAKA Toshifumi 早稲田大学, 理工学研究所, 招聘研究員 (70514470)
KAGAWA Yuki 早稲田大学, ナノ理工学研究機構, 研究員 (90409649)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | 腸内細菌 / プロバイオティクス / 炎症性疾患 |
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| Outline of Final Research Achievements |
We identified gut commensal bacteria retaining anti-inflammatory or epithelial tight junction barrier-strengthening properties by in vitro screening. Also, we characterized gut bacteria and metabolites retaining the potential to involve in colitis remission by using a dextran sulfate sodium-induced colitis mouse model. Furthermore, we developed the computational framework for elucidation of stem cell dynamics occurring in colonic crypts and quantitatively prediction of cell behavior.
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| Free Research Field |
生物工学
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