2013 Fiscal Year Final Research Report
Development and application of efficient identification method for drugable proteins based on natural products and bioorganic chemistries
| Project/Area Number |
23390026
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHISHIDO Kozo 徳島大学, ヘルスバイオサイエンス研究部, 非常勤講師 (20006349)
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| Co-Investigator(Kenkyū-buntansha) |
OTAKA Akira 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20201973)
ITOH Kohji 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (00184656)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIGENAGA Akira 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (10423394)
TSUJI Daisuke 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (00423400)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 天然物 / 不斉合成 / 創薬 / 標的タンパク / ケミカルバイオロジー / ベイト分子 / プルダウン法 / プロテオミクス |
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| Research Abstract |
Novel and highly efficient methodology for the synthesis of marine-derived natural products aspergillides A, B and C with antitumor activity was developed. It can also be applied to the synthesis of a wide variety of related compounds and we were able to have a unique compounds library, from which a new molecule with higher biological activity than the natural products was obtained. In addition, a lariat molecule that enables enrichment and selective labeling of target proteins of the bioactive compounds for efficient identification of the target proteins was successfully invented.
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Research Products
(18 results)
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[Journal Article] Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker2014
Author(s)
J. Yamamoto, N. Maeda, C. Komiya, T. Tanaka, M. Denda, K. Ebisuno, W. Nomura, H. Tamamura, Y. Sato, A. Yamauchi, A. Shigenaga, A. Otaka
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Journal Title
Tetrahedron
Volume: (印刷中)
DOI
Peer Reviewed
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[Journal Article] Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins2014
Author(s)
J. Yamamoto, M. Denda, N. Maeda, M. Kita, C. Komiya, T. Tanaka, W. Nomura, H. Tamamura, Y. Sato, A. Yamauchi, A. Shigenaga, A. Otaka
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Journal Title
Org. Biomol. Chem
Volume: vol.12
Pages: 3821-3826
DOI
Peer Reviewed
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[Journal Article] Combination with a defucosylated anti-HM1.24 monoclonal antibody plus lenalidomide induces marked ADCC against myeloma cells and their progenitors2013
Author(s)
T. Harada, S. Ozaki, A. Oda, D. Tsuji, A. Ikegame, M. Iwasa, K. Udaka, S. Fujii, S. Nakamura, H. Miki, K. Kagawa, Y. Kuroda, S. Kawai, K. Itoh, H. Yamada-Okabe, T. Matsumoto, M. Abe
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Journal Title
PLoS One
Volume: vol.26; 8(12)
Pages: e83905
DOI
Peer Reviewed
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