2013 Fiscal Year Final Research Report
Auotoimmune deseases driven with sex difference
| Project/Area Number |
23390429
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ARAKAKI Rieko 徳島大学, ヘルスバイオサイエンス研究部, 助教 (00193061)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 自己免疫疾患 / シェーグレン発症群 / エストロゲン欠乏 / 性差 / 肥満 / 性差 |
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| Research Abstract |
Physiological gender differences in immune system are well recognized and suggested that sex steroid hormones such as estrogen may be involved in the regulation of autoimmunity. We show that estrogen deficiency induces apoptosis of target cells and enhances the inflammatory lesion and Th17 cells in the salivary gland of Sjogrens syndrome (SS) model mice. By the adoptive transfer of cervical lymph node cells from NOD mice (SS model mice) into NOD/scid mice, estrogen deficiency enhances inflammatory lesions in Ovx-NOD/scid mice than Sham-NOD/scid mice. These results show that estrogen deficiency may play a pivotal role for gender-based autoimmunity in postmenopausal women.
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[Journal Article] Fas-Independent T-Cell Apoptosis by Dendritic Cells Controls Autoimmune Arthritis in MRL/lpr Mice2012
Author(s)
Takashi Izawa, Tomoyuki Kondo, Mie Kurosawa, Ritsuko Oura, Kazuma Matsumoto, Eiji Tanaka, Akiko Yamada, Rieko Arakaki, Yasusei Kudo, Yoshio Hayashi and Naozumi Ishimaru
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Journal Title
PLoS ONE
Volume: Vol.7, No.12
Pages: e48798
DOI
Peer Reviewed
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