2013 Fiscal Year Final Research Report
Development of low invasive cerebral infarction model on Common Marmoset for cell therapy and regenerative medicine.
| Project/Area Number |
23500417
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Keio University |
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Principal Investigator |
HARA Koichi 慶應義塾大学, 医学部, 客員講師 (60255479)
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| Co-Investigator(Renkei-kenkyūsha) |
OKANO Hideyuki 慶應義塾大学, 医学部, 教授 (60160694)
ITO Toshio (財)実験動物中央研究所, マーモセット研究部, 部長 (20106644)
HIKISHIMA Keigo (財)実験動物中央研究所, 画像解析部, 研究員 (30420219)
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| Research Collaborator |
INOUE Satoshi 慶應義塾大学, 医学部, 助教 (70445378)
SAWAMOTO Kazunobu 名古屋市立大学, 医学部, 教授 (90282350)
KANEKO Naoko 名古屋市立大学, 医学部, 助教 (20464571)
TOYODA Fumika (財)実験動物中央研究所, マーモセット研究部, 研究員
KOMAKI Yuji (財)実験動物中央研究所, 画像解析部, 研究員 (10548499)
USHIBA Junichi 慶應義塾大学, 理工学部生命情報学科, 准教授 (00383985)
TAKEMI Mitsuaki 慶應義塾大学, 理工学研究科, 大学院生
TSUKADA Hideo 浜松ホトニクス・中央研究所, PET センター, センター長 (10393951)
IWATA Hiroshi 島津製作所, 経営戦略室次世代医療事業推進グループ
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| Project Period (FY) |
2011 – 2013
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| Keywords | マーモセット脳梗塞モデル / 低侵襲手術 / 脳梗塞治療 / 神経新生 / 細胞移植 / 動物モデルPET |
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| Research Abstract |
Low invasive cerebral infarction model has been established on Common Marmoset without craniotomy reported in the past. The model can be made by reproducible method. The model suffers from motor hemiparesis as human. The neurological deficit can be evaluated by using neurological scorings and high speed camera. Neuroradiological assessment is also possible by using MRI and PET. Then this model is considered to be closed to human brain infarction. Histological study was also performed to analize regeneration around infarctional lesion in our model. However, neural regeneration was observed slightly. To establish cell therapy for brain infarction expecting neural regeneratoin, stem cell transplantation was performed into the basal ganglia in the model by stereotactic operation. In this operation, no complicaion was seen intra and after operation on the model. The cell transplantation model is analyzed now. Our model is considered to be extremely useful for study cerebral infarction.
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