2013 Fiscal Year Final Research Report
Development of Synthetic Methods of Glycerophospholipids Using HWE Reaction as a Key Reaction
| Project/Area Number |
23590007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SANO Shigeki 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (20226038)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Michiyasu 徳島大学, 大学院ヘルスバイオサイエンス研究部, 助教 (60550001)
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| Project Period (FY) |
2011 – 2013
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| Keywords | グリセロリン脂質 / ホスホン酸エステル / リン酸ジエステル / ＨＷＥ反応 / ホスファチジン酸 / ホスファチジルコリン / ホスファチジルエタノールアミン / フッ素原子 |
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| Research Abstract |
Glycerophospholipids are main components of the cell membrane and play an important role as second messengers in cells. Therefore, mixed phosphonoacetates have been investigated as protected precursors for the synthesis of glycerophospholipids, such as phosphatidic acid, phosphatidylcholine,and phosphatidylethanolamine. As a result, we have developed an effective and convenient synthetic method of glycerophospholipids utilizing Horner-Wadsworth-Emmons reaction (HWE reaction) as a key reaction.
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