2013 Fiscal Year Final Research Report

Pharmacological treatment for chronic spinal cord damage with special reference to blood-spinal barrier

Research Project

Project/Area Number	23592166
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Orthopaedic surgery
Research Institution	The University of Tokushima
Principal Investigator	KATOH Shinsuke 徳島大学, 大学病院, 教授 (30243687)
Co-Investigator(Kenkyū-buntansha)	HIGASHINO Kosaku 徳島大学, ヘルスバイオサイエンス研究部, 助教 (80380129) ENISHI Tetsuya 徳島大学, 大学病院, 特任助教 (20467806)
Project Period (FY)	2011 – 2013
Keywords	脊髄障害 / 薬物療法
Research Abstract	Compression myelopathy is increasing as the aging of society increases. Complications sometimes make the aged patients unable to undertake decompression surgery. Therefore, development of novel pharmacological strategy for chronic spinal cord damage is needed. We planned to develop new chronically spinal cord compression animals which show stable neurological deficits. We showed apoptosis in the neuron and glial cells in chronically compressed spinal cord. Blood-spinal cord barrier was disrupted using horse raddish peroxidase injection study. However, we failed to develop the animals with stable neurological deficit animals. We failed to demonstrate the effect of drugs on neurological function.