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2013 Fiscal Year Final Research Report

Establishment of prophylactic vaccination for bladder cancer

Research Project

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Project/Area Number 23592342
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionSapporo Medical University

Principal Investigator

KITAMURA Hiroshi  札幌医科大学, 医学部, 講師 (00404674)

Co-Investigator(Kenkyū-buntansha) SATO Noriyuki  札幌医科大学, 医学部, 教授 (50158937)
TORIGOE Toshihiko  札幌医科大学, 医学部, 准教授 (20301400)
MASUMORI Naoya  札幌医科大学, 医学部, 教授 (20295356)
Project Period (FY) 2011 – 2013
Keywords腫瘍学 / がんワクチン
Research Abstract

Peptides SVNC-S, containing an MHC class I-restricted epitope, and SVNC-L, containing MHC class I- and II-restricted epitopes, were derived from the amino acid sequence of survivin. Vaccination with SVNC-L induced a more powerful immune response than that with SVNC-S. The SVNC-L vaccination resulted in more significant suppression of the tumour growth than vaccination with SVNC-S. The SVNC-L vaccination also prevented BBN-induced bladder carcinogenesis.

  • Research Products

    (13 results)

All 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Clinicopathological analysis of patients with non- muscle-invasive bladder cancer : Prognostic value and clinical reliability of the 2004 WHO classification system2013

    • Author(s)
      Nishiyama N, Kitamura H, Maeda T, Takahashi S, Masumori N, Hasegawa T and Tsukamoto T
    • Journal Title

      Jpn J Clin Oncol

      Volume: 43 Pages: 1124-1131

    • DOI

      10.1093/jjco/hyt120

    • Peer Reviewed
  • [Journal Article] 尿路上皮癌に対する治療の最前線2013

    • Author(s)
      北村寛、舛森直哉
    • Journal Title

      細胞

      Volume: 45 Pages: 654-657

  • [Journal Article] Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma2013

    • Author(s)
      Kitamura H, Torigoe T, Hirohashi Y, Asanuma H, Inoue R, Nishida S, Tanaka T, Masumori N, Sato N, Tsukamoto T
    • Journal Title

      Virchows Arch

      Volume: 462 Pages: 101-107

    • DOI

      10.1007/s00428-012-1343-7

    • Peer Reviewed
  • [Journal Article] Potential survival benefit of anti- apoptosis protein, survivin-derived peptide vaccine with and without interferon alpha therapy for patients with advanced or recurrent urothelial cancer : results from phase I clinical trials2013

    • Author(s)
      Tanaka T, Kitamura H, Inoue R, Nishida S, Takahashi-Takaya A, Kawami S, Torigoe S, Hirohashi Y, Tsukamoto T, Sato N, Masumori N
    • Journal Title

      Clin Dev Immunol

      Volume: 2013 Pages: 262967

    • DOI

      10.1155/2013/262967

    • Peer Reviewed
  • [Journal Article] Clinicopathological analysis of patients with nonmuscle- invasive bladder cancer who under- went radical cystectomy2012

    • Author(s)
      Nishiyama N, Kitamura H, Mutoh M, Yanase M, Iwaki H, Hasegawa T, Tsukamoto T
    • Journal Title

      Surg Sci

      Volume: 3 Pages: 347-352

    • DOI

      10.4236/ss.2012.37068

    • Peer Reviewed
  • [Presentation] 再発膀胱癌患者に対するHLA-A24拘束性サバイビンペプチドワクチン予防投与2013

    • Author(s)
      北村寛、田中俊明
    • Organizer
      第26回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      盛岡市
    • Year and Date
      20131205-06
  • [Presentation] 転移性尿路上皮癌に対するHLA A24拘束性サバイビンペプチドワクチン療法の効果と治療前全身炎症反応に基づいた予後スコアについての検討2013

    • Author(s)
      田中俊明、北村寛
    • Organizer
      第26回日本バイオセラピィ学会学術集会総会
    • Place of Presentation
      盛岡市
    • Year and Date
      20131205-06
  • [Presentation] Preclinical study of a novel immunotherapy for renal cell carcinoma : combination of long and short peptides2013

    • Author(s)
      Kitamura H, Torigoe T, Hirohashi Y, Kawami S, Inoue R, Nishida S, Tanaka T, Masumori N, Sato N
    • Organizer
      5th European Multidisciplinary Meeting on Urological Cancers
    • Place of Presentation
      Marseille, France
    • Year and Date
      20131115-17
  • [Presentation] BCG failureをきたした筋層非浸潤性膀胱癌の予後に関する後ろ向き・多施設共同研究2013

    • Author(s)
      西山直隆、堀田裕、高橋敦、柳瀬雅裕、伊藤直樹、立木仁、宮尾則臣、松川雅則、国島康晴、田口圭介、北村寛、舛森直哉
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      20131024-26
  • [Presentation] Clinicopatholo- gical analysis of patients with nonmuscle- invasive bladder cancer : Prognostic value and clinical reliability of the WHO grading system of 20042013

    • Author(s)
      Nishiyama N, Kitamura H, Masumori N, Hasegawa T, Ts ukamoto T
    • Organizer
      AUA Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      20130504-08
  • [Presentation] 局所進行・有転移尿路上皮癌"尿路上皮癌に対する化学療法:一次、二次化学療法さらにはunfit症例に対する治療をどうするか?2013

    • Author(s)
      北村寛
    • Organizer
      第101回日本泌尿器科学会総会
    • Place of Presentation
      札幌市(シンポジウム)
    • Year and Date
      20130425-28
  • [Remarks] 札幌医科大学医学部泌尿器科学講座:臨床試験

    • URL

      http://web.sapmed.ac.jp/uro/advancedmedicine/index.html

  • [Remarks] 札幌医科大学医学部泌尿器科学講座:研究紹介

    • URL

      http://web.sapmed.ac.jp/uro/research/index.html

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Published: 2015-07-16  

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