Basic and clinical aspects of LUTS induced by cold stress

2013 Fiscal Year Final Research Report

• Project/Area Number: 23592364
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Shinshu University
• Principal Investigator: NISHIZAWA Osamu 信州大学, 医学部, 教授 (60091815)
• Co-Investigator(Kenkyū-buntansha): TANABE Tomoaki 信州大学, 医学部附属病院, 助教 (30293525)
• Project Period (FY): 2011 – 2013
• Keywords: 冷えストレス / 国際前立腺症状スコア / 過活動膀胱症状スコア / アドレナリン受容体 / 膀胱粘膜 / セロトニン受容体 / 大建中湯

Research Abstract

Lower urinary tract symptoms(LUTS) induced by cold stress has not been sufficiently studied. Autonomic nervous system receptors mRNA were analyzed in bladder mucosa of patients with LUTS/benign prostatic obstruction. There was an increased expression of alpha 1d-AR, beta 3 AR, serotonin 2b, 3a, 7 mRNA in the bladder mucosa. Serotonin mechanism may take a role in LUTS induced by cold stress. 50 people who visited a public health management seminar were studied. The participants were devided into two groups-cold sensitive and non-sensitive- according to self-described sensitivity to cold stress. Daily exercise and lifestyle modification was effective for LUTS in cold sensitive people. Daikenchuto, a pharmaceutical-grade traditional Japanese medicine, were administered to the refratory LUTS patients with constipation or cold sensitivity. Daikenchuto improved LUTS suggesting as a consequence of improvement of constipation or cold sensitivity.

Research Products

• [Journal Article] Alpha1-adrenergic receptors mediate bladder overactivity induced by cold stress in rats with bladder outlet obstruction (2014)
  • Author(s): Yamagishi, T., Ishizuka, O., Imamura, T., Yokoyama, H., Ogawa, T., Kurizaki, Y., Nishizawa, O., Andersson, K.-E.
  • Journal Title: Neurourol. Urodyn Volume: (in press)
  • Peer Reviewed
• [Journal Article] Correlation between bladder mucosal alpha- 1D/alpha-1A adrenoceptor mRNA ratio and lower urinary tract function in benign prostatic obstruction patients (2013)
  • Author(s): Kurizaki, Y., Ishizuka, O., Imamura, T., Ichino, M., Nishizawa, O.
  • Journal Title: LUTS Volume: 5 Pages: 60-64
  • Peer Reviewed
• [Journal Article] Relationship between expression of beta3-adrenoceptor mRNA in bladder mucosa and urodynamic findings in men with lower urinary tract (2013)
  • Author(s): Kurizaki, Y., Ishizuka, O., Imamura, T., Nishizawa, O., Andersson, K.-E.
  • Journal Title: Neurourol. Urodyn Volume: 32 Pages: 88-91
  • Peer Reviewed
• [Journal Article] The relationship between toe temperature and lower urinary tract symptoms (2012)
  • Author(s): Inoue, H., Ishizuka, O., Imamura, T., Yamagishi, T., Noguchi, W., Yokoyama, H., Kurizaki, Y., Nishizawa, O.
  • Journal Title: LUTS Volume: 4 Pages: 144-149
  • Peer Reviewed
• [Presentation] Effects of herbal medicine Daikenchuto on patients of refractory overactive bladder or lower urinary tract symptoms with constipation or hypersensitivity to cold (2013)
  • Author(s): Minagawa, T., Noguchi,W., Ogawa, T., Imamura, T., Kato, H., Ishizuka, O., Nishizawa, O.
  • Organizer: 43^<rd> of the Annual meeting of the International continence society
  • Place of Presentation: Barcelona
  • Year and Date: 20130826-30
• [Presentation] 冷え・便秘を合併する排尿障害に対する大建中湯の治療効果 (2013)
  • Author(s): 皆川倫範,野口渉,小川輝之,横山仁,市野みどり,栗崎功己,加藤晴朗,石塚修,西澤理
  • Organizer: 第20回日本排尿機能学会
  • Place of Presentation: 静岡
  • Year and Date: 2013-09-21
• [Presentation] 下部尿路閉塞ラットの冷えストレス誘発排尿筋過活動におけるα1アドレナリン受容体とムスカリン受容体の機能的役割の検討 (2013)
  • Author(s): 山岸貴裕,石塚修,今村哲也,野口渉,横山仁,小川輝之,栗崎功己,西澤理
  • Organizer: 第20回日本排尿機能学会
  • Place of Presentation: 静岡
  • Year and Date: 2013-09-21
• [Presentation] Alpha1D-adrenergic plays important role for cold stress-induced detrusor overactivity in rats with bladder outlet obstruction (2013)
  • Author(s): Yamagishi, T., Ishizuka, O., Imamura, T., Noguchi, W., Yokoyama, H., Kurizaki, Y., Nishizawa, O.
  • Organizer: 108^<th> of the Annual meeting of the American urological association
  • Place of Presentation: San Diego
  • Year and Date: 2013-05-04
• [Presentation] 冷え・便秘を合併する排尿障害に対する大建中湯の治療効果 (2013)
  • Author(s): 皆川倫範,野口渉,小川輝之,横山仁,市野みどり,栗崎功己,加藤晴朗,石塚修,西澤理
  • Organizer: 第31回泌尿器科漢方研究会
  • Place of Presentation: 札幌
  • Year and Date: 2013-04-26
• [Presentation] 下部尿路閉塞モデルラットにおける冷えストレス誘発排尿筋過活動に対するナフトピジルの薬理効果の検討 (2013)
  • Author(s): 山岸貴裕,石塚修,今村哲也,野口渉,横山仁,小川輝之,栗崎功己,西澤理
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2013-04-26
• [Presentation] 冷え・便秘を合併する排尿障害に対する大建中湯の治療効果 (2013)
  • Author(s): 皆川倫範,西澤理,野口渉,小川輝之,横山仁,市野みどり,栗崎功己,加藤晴朗,石塚修
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2013-04-26
• [Presentation] Correlation between bladder mucosal alpha- 1D/alpha-1A adrenoceptor mRNA ratio and lower urinary tract function in benign prostatic obstruction patients (2012)
  • Author(s): Kurizaki, Y., Ishizuka, O., Imamura, T., Ichino, M., Nishizawa, O.
  • Organizer: 2^<nd> congress of Asian pacific prostate society
  • Place of Presentation: Seoul
  • Year and Date: 20120413-14
• [Presentation] 下部尿路症状と下肢温度との関係についての検討 (2012)
  • Author(s): 山岸貴裕,石塚修,今村哲也,井上博夫,野口渉,横山仁,栗崎功己,小川輝之,石川雅邦,市野みどり,西澤理
  • Organizer: 第19回日本排尿機能学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-08-30
• [Presentation] 下部尿路症状を有する男性の膀胱上皮に発現しているα1アドレナリン受容体mRNAのalpha1D/alpha1A比と膀胱機能検査所見との関係 (2012)
  • Author(s): 栗崎功己,石塚修,今村哲也,市野みどり,小川輝之,石川雅邦,西澤理
  • Organizer: 第19回日本排尿機能学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-08-29