2012 Fiscal Year Final Research Report
New method of differential diagonosis and tailor- made treatmentfor hepatocellular carcinoma by antisense RNA
| Project/Area Number |
23650611
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnosis
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUNAGA Kiyoshi 筑波大学, 医学医療系, 講師 (20361339)
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| Project Period (FY) |
2011 – 2012
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| Keywords | バイオマーカー / アンチセンスRNA / 肝癌 / スクリーニング |
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| Research Abstract |
The molecular mechanisms of hepatocellular carcinoma (HCC) initiation remain mclear. Recent reports have demonstrated that natural antisense transcripts with complementary sequences to messenger RNA have important functions such as the stabilization and silencing of mRNA. We innestigated the regulation of natural antisense transcripts (NATs) in human HCC for their possible involvement in HCCdevelopment. We identified as up- and down-regulated in HCC tissues, compared to non-cancerous liver tissue. We also focused on HCV-associated HCCs and evaluated. Differential expression of antisense transcripts was observed between HCC and non-cancerous tissue. The sense and antisense expression profiles were analyzed with regard to histological faindings of HCC. We clarifeid different expression of NATs among the histological faindings of HCC.
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Research Products
(6 results)
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[Journal Article] Comprehensive expressional analyses of antisense transcripts in colon cancer tissues using artificial antisense probes.2011
Author(s)
Saito R, Kohno K, Okada Y, Osada Y, Numata K, Kohama C, Watanabe K, Nakaoka H, Yamamoto N, Kanai A, Yasue H, Murata S, Abe K, Tomita M, Ohkohchi N, Kiyosawa H
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Journal Title
BMC Med Genomics.
Volume: 16
Pages: 42
DOI
Peer Reviewed
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