2012 Fiscal Year Final Research Report
Search for novel natural products using chemical inhibitors modifying epigentics
| Project/Area Number |
23651212
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 糸状菌 / 二次代謝物 / エピジェネティクス / 酵素阻害剤 |
|---|
| Research Abstract |
Epigenetic manipulation of fungal gene expression using HDAC and DNA methyltransferase inhibitors indeed seems to be an effective method for accessing natural products obtained from cryptic biosynthetic pathways. We applied the inhibitors to our natural product exploration from fungal cultures. Thus, we have demonstrated that the method is definitely efficient to enhance the fungal secondary metabolite productions and discover novel natural products.
|
Research Products
(25 results)
