2012 Fiscal Year Final Research Report
Molecular mechanism of metabolic regulation by TRPM7
| Project/Area Number |
23659114
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATAGIRI Chiaki 琉球大学, 大学院・医学研究科, 助教 (00443664)
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| Project Period (FY) |
2011 – 2012
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| Keywords | TRPM7 / チャネル / キナーゼ / コレステロール代謝 |
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| Research Abstract |
We have made the kinase dead knock-in mouse with replacement of the key residue for ATP binding in kinase domain to investigate a possible role of kinase activity f TRPM7. This mutant mouse grows normally, but show significant abnormality of cholesterol metabolism. In addition, we identified the cholesterol secretion from hepatocyte was severely defect in these mutant mouse.
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Research Products
(5 results)
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[Journal Article] Shimabukuro M, Masuzaki H. Brown rice and its component, γ-oryzanol, attenuate the preference for high-fat diet by decreasing hypothalamic endoplasmic reticulum stress in mice2012
Author(s)
Kozuka C, Yabiku K, Sunagawa S, Ueda R, Taira S, Ohshiro H, Ikema T, Yamakawa K, Higa M, Tanaka H, Takayama C, Matsushita M, Oyadomari S, Shimabukuro M, Masuzaki H
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Journal Title
DOI
Peer Reviewed
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