2013 Fiscal Year Final Research Report
The development of anticancer effect by DNA polymerase inhibitory of vitamin K derivatives
| Project/Area Number |
23710262
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Living organism molecular science
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
KURIYAMA Isoko 神戸学院大学, 栄養学部, 研究員 (50553749)
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| Project Period (FY) |
2011 – 2013
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| Keywords | DNA合成酵素 / ビタミンK / 酵素阻害剤 |
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| Research Abstract |
It was investigated and analyzed the effect of vitamin K derivative and acylate compound on the inhibition of mammalian DNA polymerase (pol) species and anti-cancer. Juglone and plumbagin inhibited the activities of DNA pols and suppressed cellular proliferation. Juglone showed that the combined effect of UV-irradiation, furthermore the mutation rate of the treatment decreased. C18:1 plumbagin was the most strong inhibitor and suppressed the growth of colon cancer cells. C18:1 plumbagin showed more potent antitumor activity than its C18:1 juglone. There were no effects on body weight.
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[Journal Article] Effects of essential oils from herbal plants and citrus fruits on DNA polymerase inhibitory, cancer cell growth inhibitory, antiallergic, and antioxidant activities2012
Author(s)
Mitoshi M, Kuriyama I, Nakayama H, Miyazato H, Sugimoto K, Kobayashi Y, Jippo T, Kanazawa K, Yoshida H, Mizushina Y
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Journal Title
J Agric Food Chem
Volume: 60(45)
Pages: 11343-11350
Peer Reviewed
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