2012 Fiscal Year Final Research Report
ER redox regulation by ER GSH transporter
| Project/Area Number |
23770158
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
HOSEKI Jun 京都大学, 生理化学研究ユニット, 特定准教授 (40423058)
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| Project Period (FY) |
2011 – 2012
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| Keywords | レドックス / 小胞体 |
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| Research Abstract |
Glutathione is required for ER redox regulation. GSH is synthesized in cytosol while the mechanism by which GSH is transported into the ER is still unknown. We showed that ER membrane proteins are necessary for GSH transport into the ER and identified inhibitors for GSH transport into the ER by a sensitive detection system using roGFP for GSH transport into the ER.
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