Role of podoplanin in epidermal keratinocytes and psoriatic epidermis

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791246
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Asahikawa Medical College
• Principal Investigator: HONMA Masaru 旭川医科大学, 医学部, 講師 (50344578)
• Project Period (FY): 2011 – 2012
• Keywords: 表皮角化細胞 / 有棘細胞癌 / 皮膚癌 / 幹細胞 / 分化 / 角化 / 浸潤能 / 遊走能

Research Abstract

Our results of epidermal keratinocytes show that podoplanin is associated with the regulatory mechanism of cell adhesion and self-renewal potency. This mechanism reflects both increased proliferating pool and increased transition into differentiation process of keratinocytes in prosiatic epidermis. In addition, we revealed the novel cell density-dependent PDPN-induction mechanism in squamous cell carcinoma cell-lines, which might play an important role in tumor progression process.

Research Products

• [Journal Article] P Podoplanin suppressess cell adhesion by inhibiting β1-integrin function and initiates differentiation of human epidermal keratinocytes (2013)
  • Author(s): Honma M, Fujii M, Takahashi H, et al
  • Volume: (submitted)
• [Journal Article] Analytical prognostic survey of 105 Japanese cases of cutaneous T-cell lymphoma: clusterin expression as a novel prognostic factor (2013)
  • Author(s): Tobisawa S, Honma M, et al
  • Journal Title: J Dermatol Sci Volume: (in press)
• [Journal Article] Japanese patients with psoriasis and atopic dermatitis show distinct personality profiles (2013)
  • Author(s): Takahashi H, Tsuji H, Honma M, et al
  • Journal Title: J Dermatol Volume: (in press)
• [Journal Article] Increased plasma resistin and decreased omentin levels in Japanese patients with psoriasis (2013)
  • Author(s): Takahashi H, Tsuji H, Honma M, et al
  • Journal Title: Arch Dermatol Res Volume: (in press)
• [Journal Article] Podoplanin-expression is inversely correlated with granular layer/filaggrin formation in psoriatic epidermis (2013)
  • Author(s): Honma M, Fujii M, Iinuma S, et al
  • Journal Title: J Dermatol Volume: (in press)
• [Journal Article] Intercellular contact augments EGF receptor expression to activate STAT3 which increases podoplanin expression in order to promote squamous cell carcinoma motility (2013)
  • Author(s): Fujii M, Honma M, Takahashi H, et al
  • Journal Title: Cell Signal Volume: 25(4) Pages: 760-5
• [Journal Article] Patients with psoriasis and atopic dermatitis show distinct anxiety profiles (2012)
  • Author(s): Takahashi H, Tsuji H, Honma M, et al
  • Journal Title: J Dermatol Volume: 6
  • DOI: doi:10.1111/j.1346-8138.2012.01513.x.
• [Journal Article] Podoplanin Expression in Wound and Psoriatic Epidermis: Regulation by TGF-β and STAT-3 Activating Cytokines, IFN-γ, IL-6, and IL-22 (2012)
  • Author(s): Honma M, Minami-Hori M, Takahashi H, Iizuka H.
  • Journal Title: J Dermatol Sci Volume: 65(2) Pages: 134-40
• [Journal Article] Rho-kinase inhibitor, Y27632, alters expression of perilipin and adipophilin during differentiation of hamster sebocyte (2012)
  • Author(s): Kaneta K, Honma M, Kishibe M, Iizuka H.
  • Journal Title: J Dermatol Volume: 39(7) Pages: 641-4
• [Journal Article] NF-κB p50 subunit and Cortactin as differentiation markers between keratoacanthoma and well differentiated squamous cell carcinoma (2011)
  • Author(s): Fujii M, Honma M, Takahashi H, et al
  • Journal Title: Clin Exp Dermatol Volume: 36(7) Pages: 788-92
• [Journal Article] Tight junction-related multilayered network structures in mammalian epidermis
  • Author(s): Ishida-Yamamoto A, Kishibe M, Murakami M, Honma M, et al
  • Journal Title: PLoS ONE Volume: 7(2) Pages: e31641
• [Presentation] Upregulated podoplanin-expression depending on cellular density contributes to increased cell motility of squamous cell carcinoma cells (2013)
  • Author(s): Fujii M, Honma M, Takahashi H, Ishida-Yamamoto A, Iizuka H
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 20130500
• [Presentation] Podoplanin alters β1-integrin-mediated cell adhesion and initiates terminal differentiation of human epidermal keratinocytes (2013)
  • Author(s): Honma M, Fujii M, Takahashi H Iizuka H
  • Organizer: International Investigative Dermatology
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 20130500
• [Presentation] 表皮角化細胞におけるpodoplanin分子によるβ1-integrin (2013)
  • Author(s): 本間 大、飯塚 一
  • Organizer: 制御機構 第20回分子皮膚科学フォーラム
  • Place of Presentation: 東京
  • Year and Date: 20130400
• [Presentation] Podoplanin alters β1-integrin-mediated cell adhesion and initiates terminal differentiation in human epidermal keratinocytes (Concurrent oral session) (2012)
  • Author(s): Honma M, Fujii M, Takahashi H, Iizuka H
  • Organizer: 日本研究皮膚科学会第37回年次学術大会・総会
  • Place of Presentation: 那覇
  • Year and Date: 20121200
• [Presentation] Upregulated podoplanin-expression depending on cellular density contributes to increased cell motility of squamous cell carcinoma cells (Concurrent oral session) (2012)
  • Author(s): Fujii M, Honma M, Takahasi H, Ishida-Yamamoto A, Iizuka H
  • Organizer: 日本研究皮膚科学会第37回年次学術大会・総会
  • Place of Presentation: 那覇
  • Year and Date: 20121200
• [Presentation] Upregulated podoplanin-expression depending on cellular density contributes to increased cell motility of squamous cell carcinoma cells (2012)
  • Author(s): 藤井瑞恵、本間 大、飯塚 一
  • Organizer: 第19回分子皮膚科学フォーラム
  • Place of Presentation: 青森
  • Year and Date: 20120400
• [Presentation] Podoplanin induces upregulated cell motility through activation of cofiin and matrix metalloproteinase-9 in HaCaT cells (2011)
  • Author(s): Fujii M, Honma M, Takahashi H, Ishida-Yamamoto A, Iizuka H
  • Organizer: 日本研究皮膚科学会第36回年次学術大会・総会
  • Place of Presentation: 京都
  • Year and Date: 20111200
• [Presentation] 表皮角化細胞の接着・分化におけるポドプラニン分子の機能 (2011)
  • Author(s): 本間 大、飯塚 一
  • Organizer: 第25回表皮細胞研究会
  • Place of Presentation: 横浜
  • Year and Date: 20111000
• [Presentation] Novel corneodesmosin null mutation and entire gene deletion in two families with inflammatory peeling skin syndrome (2011)
  • Author(s): Furio L, Honma M, Deraison C, Robin A, Tron E, Sans B, Gardini-Fournie E, Igawa S, Murakami M, Prost C, Ishida-Yamamoto A, Hovnanian A
  • Organizer: 71th Annual Meeting of Society for Investigative Dermatology
  • Place of Presentation: Phoenix, USA
  • Year and Date: 20110500