2012 Fiscal Year Final Research Report
Molecular mechanism of the differentiation control by the mechanical stimulation of the mesenchymal cells which is in the process of chondrocyte differentiation
| Project/Area Number |
23792414
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
KUMIKO Kosaka 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (30585336)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 機械的刺激 / 軟骨細胞分化 / MAPK |
|---|
| Research Abstract |
In this study, I found that mechanical compressive stimulation promoted chondrogenic differentiation of mesenchymal cells derived from rat lim bud but stretch stimulation inhibited it. In addition, phosphorylation and nuclear translocation of ERK-1/2 were observed after mechanical stretch stimulation. Therefore, activation of ERK-1/2 pathway by mechanical stimulation is involved in mechano-sensing signaling pathway of chondrogenesis.
|
