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2012 Fiscal Year Final Research Report

Molecular mechanism of the differentiation control by the mechanical stimulation of the mesenchymal cells which is in the process of chondrocyte differentiation

Research Project

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Project/Area Number 23792414
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTohoku University

Principal Investigator

KUMIKO Kosaka  東北大学, 大学院・歯学研究科, 大学院非常勤講師 (30585336)

Project Period (FY) 2011 – 2012
Keywords機械的刺激 / 軟骨細胞分化 / MAPK
Research Abstract

In this study, I found that mechanical compressive stimulation promoted chondrogenic differentiation of mesenchymal cells derived from rat lim bud but stretch stimulation inhibited it. In addition, phosphorylation and nuclear translocation of ERK-1/2 were observed after mechanical stretch stimulation. Therefore, activation of ERK-1/2 pathway by mechanical stimulation is involved in mechano-sensing signaling pathway of chondrogenesis.

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Published: 2014-09-25  

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