2012 Fiscal Year Final Research Report
Relationship between Mucosal Immune Response to Phosphorylcholineand atherosclerosis
| Project/Area Number |
23792515
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
GOTO Masaki 徳島大学, 大学院・ソシオテクノサイエンス研究部, 助教 (30507455)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 粘膜免疫 / ホスホリルコリン / 動脈硬化 / 口腔常在菌 |
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| Research Abstract |
Antibody levels in sera and mucosal secretions following the nasal vaccination with PC-KLH were facilitated by coadministration of LPS. LPS can be used as a mucosal adjuvant as an alternative to CT. From an epidemiological survey, antibody levels of the huma n anti-PC IgM in plasma associated with the risk for the atherosclerosis but the periodontal condition must be considered in analysis of the atherosclerosis.
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