2023 Fiscal Year Research-status Report
Elucidation of the Molecular Mechanisms Behind Avascular Necrosis
| Project/Area Number |
23K14502
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| Research Institution | Osaka University |
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Principal Investigator |
ZEYNEP BAL 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (40924064)
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| Project Period (FY) |
2023-04-01 – 2025-03-31
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| Keywords | osteonecrosis / vascularisation / bone regeneration / vascular regeneration / stem cells |
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| Outline of Annual Research Achievements |
Osteonecrosis of the Femoral Head (ONFH) is an osteonecrotic condition with a high rate of disability, originated from the inadequate blood supply to femoral head and the molecular aetiology behind traumatic ONFH has not been clarified yet. Thus we aimed to develop a mice trauma model to study the traumatic ONFH in detail and with in one year the model was able to be developed and the changes in vascularisation between necrotic bone and healthy bone are started to be observed already.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
The method in animal experiment has changed.
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| Strategy for Future Research Activity |
Until now, we almost developed a mice model for traumatic ONFH and we started to observe the differences in vascular structures in necrotic femoral head and heathy one. From now on the vascularisation process in necrotic bone tissue and healthy bone tissue will be observed as well as the macrophage and neutrophil changes in two different situations. Also a treatment strategy with the help of an EC side population will try to be developed. Meanwhile if there will be a chance we also want to observe the differences between steroid induced ONFH and traumatic ONFH in disease development.
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| Causes of Carryover |
Starting from this fiscal year, the delayed period will be covered with experiments and also the research and review papers regarding the topic will be published. International and national congresses are planning to be attended. Additionally the reagents, antibodies, experiment animals and staining materials related to the experiment as well as the imaging related reagents will be purchased.
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