Mechanism of signal transduction regulating axon regeneration

2015 Fiscal Year Final Research Report

• Project/Area Number: 24247025
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Nagoya University
• Principal Investigator: MATSUMOTO Kunihiro 名古屋大学, 理学(系)研究科(研究院), 教授 (70116375)
• Co-Investigator(Renkei-kenkyūsha): HISAMOTO Naoki 名古屋大学, 大学院理学研究科, 准教授 (80283456) ; HANAFUSA Hiroshi 名古屋大学, 大学院理学研究科, 准教授 (00345844)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 遺伝学 / シグナル伝達 / 神経科学 / 脳・神経 / 軸索再生

Outline of Final Research Achievements

The ability of neurons to regenerate their axons after injury is determined by a balance between signaling pathways that promote and inhibit regeneration. In Caenorhabditis elegans, JNK MAP kinase pathway is important for axon regeneration. We demonstrated that the SVH-1 growth factor and its receptor SVH-2 regulate axon regeneration via the JNK MAPK. We also found that the endocannabinoid anandamide (AEA) inhibits axon regeneration via the Goα; subunit GOA-1, which antagonizes the JNK pathway. In this study, we showed that a signaling network consisting of multiple pathways regulates axon regeneration via the JNK pathway.

Free Research Field

分子遺伝学