2014 Fiscal Year Final Research Report
Mode of functions of plasmid as the modulator of host chromosomal functions
Project/Area Number |
24380043
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Applied microbiology
|
Research Institution | The University of Tokyo |
Principal Investigator |
NOJIRI Hideaki 東京大学, 生物生産工学研究センター, 教授 (90272468)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | プラスミド / 染色体 / 遺伝子発現 / 転写制御 / 核様体 |
Outline of Final Research Achievements |
To elucidate the modulation mechanism of host chromosomal functions by plasmid, the reduction of osmotic stress tolerance and the induction/reduction of the specific genes by plasmid carriage were investigated. In addition, mechanisms of dimerization/multimerization of plasmid-borne H-NS family proteins were investigated by protein-protein cross-linking assays and protein structure determined by X-ray crystallography.
|
Free Research Field |
環境微生物学
|