• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2014 Fiscal Year Final Research Report

Effect of dietary beta-glucan on the resistibility of intestinal epithelia to intestinal viruses and its mechanisms

Research Project

  • PDF
Project/Area Number 24380069
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Food science
Research InstitutionNagoya University

Principal Investigator

MATSUDA Tsukasa  名古屋大学, 生命農学研究科, 教授 (20144131)

Co-Investigator(Kenkyū-buntansha) OSHIMA Kenzi   (90391888)
Co-Investigator(Renkei-kenkyūsha) KATAYAMA Kazuhiko   (60342903)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywordsβグルカン / 腸上皮細胞 / マクロファージ / 腸管ウイルス / 食物繊維
Outline of Final Research Achievements

β-Glucan is a polysaccharide contained as a cell wall component of plant, algae, fungi, yeast, etc. It is a glucose-polymer classified into a dietary fiber because of its indigestibility. Possible absorption of dietary β-glucan and activation of intestinal immune system by the absorbed β-glucan were investigated using cell culture systems mimicking intestinal epithelia and viruses as well as virus-like particles (VLPs). β-Glucan taken up by phagocytes was degraded and released, and the released β-glucan activated neighboring cells, resulting in the release of various humoral factors. The β-glucan taken up and degraded by phagocytes was suggested to affect the resistibility of intestinal epithelia to intestinal viruses.

Free Research Field

食品科学

URL: 

Published: 2016-06-03  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi