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2015 Fiscal Year Final Research Report

Neural mechanisms underlying the circadian pacemakers

Research Project

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Project/Area Number 24390052
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field General physiology
Research InstitutionKanazawa University

Principal Investigator

Mieda Michihiro  金沢大学, 医学系, 准教授 (20296552)

Co-Investigator(Renkei-kenkyūsha) SAKURAI TAKESHI  金沢大学, 医学系, 教授 (60251055)
Project Period (FY) 2012-04-01 – 2016-03-31
Keywords概日リズム / 視交叉上核 / バソプレシン / 遺伝子操作マウス / 体内時計 / 神経ネットワーク
Outline of Final Research Achievements

The suprachiasmatic nucleus (SCN), the primary circadian pacemaker in mammals, is a network structure composed of multiple types of neurons. However, the neural mechanisms underlying the generation of robust and stable circadian oscillation by the SCN network remains unknown. We generated mice with neuron type-specific genetic manipulations and performed analyses of their behavior, gene expression in vivo and ex vivo, and so on. We found that AVP producing neurons in the SCN play a critical role in the generation of stable circadian behavioral rhythms and the determination of the circadian period.

Free Research Field

神経科学

URL: 

Published: 2017-05-10  

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