Molecular pathological analyses of Wnt5a-Ror signaling in inflammation and cancer progression accompanying epithelial-mesenchymal transition

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390080
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Kobe University
• Principal Investigator: MINAMI Yasuhiro 神戸大学, 医学(系)研究科(研究院), 教授 (70229772)
• Co-Investigator(Kenkyū-buntansha): NISHITA Michiru 神戸大学, 大学院医学研究科, 准教授 (30379359) ; ENDO Mitsuharu 神戸大学, 大学院医学研究科, 助教 (90436444)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Wnt5a-Ror / シグナル伝達 / 上皮間葉転換 (EMT) / 慢性炎症 / がんの増悪 / 組織損傷修復 / 炎症性サイトカイン

Outline of Final Research Achievements

Wnt5a-Ror signaling has been shown to be activated transiently during embryogenesis and to play important roles in developmental morphogenesis and tissue-genesis via induction of epithelial-mesenchymal transition and so on. After birth, expression levels of Wnt5a and Ror proteins are very low in general. In this study, we have shown by employing in vitro and in vivo analyses that these proteins are induced during tissue repair after injury, chronic inflammation, and progression of cancers, thereby resulting in aberrant activation of Wnt5a-Ror signaling. We have also found possible relationships between these pathological conditions and aberrant activation of Wnt5a-Ror signaling.

Free Research Field

分子細胞生物学