2014 Fiscal Year Final Research Report
Suppression mechanisms of autoimmune diseases by SATB1
| Project/Area Number |
24390121
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Fumio 東邦大学, 医学部, 講師 (10130345)
TANAKA Yuriko 東邦大学, 医学部, 助教 (40396685)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 自己免疫疾患 / 免疫寛容 / Ｔ細胞 / ネガティブセレクション |
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| Outline of Final Research Achievements |
Immune tolerance is maintained in the healthy condition; however, autoimmune diseases occur once immune tolerance is broken. We found that loss of a genome organiser, Special AT-rich binding protein-1 (SATB1), leads to autoimmune diseases in mice. In SATB1 deficient mice, negative selection, in which auto-reactive T cells are eliminated, is impaired. Therefore, SATB1 plays a critical role in establishment of immune tolerance.
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| Free Research Field |
免疫学
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