Early diagnosis and treatment of Parkinson disease dementia

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390219
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Department of Clinical Research, National Hospital Organization Sendai Nishitaga National Hospital (2014-2015); Tohoku University (2012-2013)
• Principal Investigator: TAKEDA ATSUSHI 独立行政法人国立病院機構仙台西多賀病院(臨床研究部), その他部局等, その他 (70261534)
• Co-Investigator(Kenkyū-buntansha): HASEGAWA Takafumi 東北大学, 大学院医学系研究科, 講師 (70361079) ; KIKUCHI Akio 東北大学, 大学院医学系研究科, 助教 (80463785)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: シヌクレイノパチー / 分子イメージング / レビー小体 / グリア細胞質封入体

Outline of Final Research Achievements

Dementia is now known to be the greatest risk factor for poor prognosis of Parkinson disease (PD). Thus an early diagnosis and therapeutic intervention for cognitive impairments may enable to improve the long-term prognosis of PD. In this project, we investigated the distribution and propagation process of synuclein aggregation in PD brain by using the [11C]BF-227 PET. Nine of 19 PD cases showed high uptake in limbic system such as orbitofrontal area, amygdale, and cingulate cortex. The areas of high uptake were increasing by time-dependent manner. Other cases showed little of BF-227 signals. From these results, we speculate that there may be two patterns of synuclein deposition in PD, that is, limbic type with high BF-227 signals and brainstem type without apparent BF-227 uptake, although further study by using new probes more specific for synuclein aggregation are needed to confirm the present results.

Free Research Field

神経内科学