Comprehensive analysis of exercise-induced metabolic alteration through the investigation of the function of novels isoforms of PGC1a

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390234
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kobe University
• Principal Investigator: WATARU Ogawa 神戸大学, 医学(系)研究科(研究院), 教授 (40294219)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 糖尿病 / エネルギー代謝 / 肥満 / インスリン抵抗性

Outline of Final Research Achievements

We have characterized the physiological function of novel isoforms of PGC1α mainly by the investigation of metabolic phenotypes of mice that specifically lack the genes for these isoforms. These novel isoforms, PGC1αb and PGC1αc, are greatly induced in skeletal muscle in response to exercise and increased energy expenditure through stimulating fatty acid metabolism and mitochondrial proton leakage. These isoforms also play an important role for the maintenance of exercise capacity. Novel isoforms that transcribed from the same exon as PGC1αb and PGC1αc were transcribed were identified, and termed PGC1α2, 3, and 4. PGC1α2, 3, and 4 however do not possess such metabolic function in skeletal muscle.

Free Research Field

代謝学