Development of the drugs targeting lung tumor endothelial cells and the companion diagnosis

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390324
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Hokkaido University
• Principal Investigator: Hida Yasuhiro 北海道大学, 大学病院, 准教授 (30399919)
• Co-Investigator(Kenkyū-buntansha): KAGA KICHIZO 北海道大学, 北海道大学病院, 講師 (80224335) ; MATSUI YOSHIRO 北海道大学, 大学院医学研究科, 教授 (90219379)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 肺癌 / 血管新生 / 腫瘍血管内皮細胞

Outline of Final Research Achievements

Tumor endothelial cells (TEC) from mouse xenografted tumor, especially that from highly metastatic tumor expresses high level of biglycan. Knock down of biglycan by siRNA suppressed tumor cell invasion thorough endothelial cell sheet. Co-implantation of low metastatic tumor cells with TEC developed lung metastases. This metastatic ability was abandoned by suppression of biglycan expression in TEC. Immunohistochemistry of human clinical tumors revealed specific expression of biglycan in TEC. ELISA of serum showed high biglycan level in cancer patients, especially those with metastasis.

Free Research Field

呼吸器外科